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越南胡志明市首剂 COVID-19 疫苗接种后的副作用。

Side effects following first dose of COVID-19 vaccination in Ho Chi Minh City, Vietnam.

机构信息

Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.

School of Medicine, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam.

出版信息

Hum Vaccin Immunother. 2023 Dec 31;19(1):2176066. doi: 10.1080/21645515.2023.2176066. Epub 2023 Mar 1.

DOI:10.1080/21645515.2023.2176066
PMID:36856074
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10026889/
Abstract

Vaccines are strongly recommended globally as an effective measure to prevent serious illness from and spread of COVID-19. Concerns about safety following vaccination continue to be the most common reason that people do not accept the vaccine. This retrospective study was carried out on 4341 people who received the first dose of ChAdOx1 nCoV-19, BBIBP-CorV, or mRNA-1273 vaccine at Jio Health Clinic in Ho Chi Minh City, Vietnam. Post-injection side effects were either reported by participants or actively collected by health care staff by means of telemedicine. Local side effects were reported by 35.5% of all individuals, with pain being the most common symptom (33.3%). Systemic side effects were reported by 44.2% of individuals, with fever (25.3%) and fatigue (21.4%) being the most common. Age ≤60 years, female gender, and ChAdOx1 nCoV-19 were significant independent risk factors for both local and systemic side effects, while a history of allergy was significant as a risk factor for local side effects. A total of 43 individuals (1.0%) reported concerning symptoms of rare severe complications, which were addressed and treated by physicians via Jio Health app.

摘要

疫苗被全球强烈推荐作为预防 COVID-19 严重疾病和传播的有效措施。接种疫苗后对安全性的担忧仍然是人们不接受疫苗的最常见原因。这项回顾性研究在越南胡志明市的 Jio Health 诊所对 4341 名接受 ChAdOx1 nCoV-19、BBIBP-CorV 或 mRNA-1273 疫苗第一剂的人进行了研究。注射后的副作用要么由参与者报告，要么由医疗保健人员通过远程医疗主动收集。所有个体中有 35.5%报告了局部副作用，疼痛是最常见的症状（33.3%）。全身副作用在 44.2%的个体中报告，发热（25.3%）和疲劳（21.4%）最为常见。年龄≤60 岁、女性和 ChAdOx1 nCoV-19 是局部和全身副作用的显著独立危险因素，而过敏史是局部副作用的危险因素。共有 43 人（1.0%）报告了罕见严重并发症的令人担忧的症状，通过 Jio Health 应用程序，医生对这些症状进行了处理和治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/373e/10026889/a7e2acb18855/KHVI_A_2176066_UF0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/373e/10026889/8a7f071a6839/KHVI_A_2176066_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/373e/10026889/a7e2acb18855/KHVI_A_2176066_UF0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/373e/10026889/8a7f071a6839/KHVI_A_2176066_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/373e/10026889/a7e2acb18855/KHVI_A_2176066_UF0002_OC.jpg

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