一生中接触草甘膦和氨甲基膦酸（AMPA）与青年期肝炎症和代谢综合征的关联：来自 CHAMACOS 研究的发现。

Association of Lifetime Exposure to Glyphosate and Aminomethylphosphonic Acid (AMPA) with Liver Inflammation and Metabolic Syndrome at Young Adulthood: Findings from the CHAMACOS Study.

机构信息

Center for Environmental Research and Community Health (CERCH), School of Public Health, University of California, Berkeley, Berkeley, California, USA.

Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA.

出版信息

Environ Health Perspect. 2023 Mar;131(3):37001. doi: 10.1289/EHP11721. Epub 2023 Mar 1.

DOI:10.1289/EHP11721

PMID:36856429

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9976611/

Abstract

BACKGROUND

The prevalence of liver disorders and metabolic syndrome has increased among youth. Glyphosate, the most widely used herbicide worldwide, could contribute to the development of these conditions.

OBJECTIVE

We aimed to assess whether lifetime exposure to glyphosate and its degradation product, aminomethylphosphonic acid (AMPA), is associated with elevated liver transaminases and metabolic syndrome among young adults.

METHODS

We conducted a prospective cohort study ( mother-child dyads) and a nested case-control study ( cases with elevated liver transaminases and 91 controls) using data from the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS). We measured glyphosate and AMPA concentrations in urine samples collected during pregnancy and at child ages 5, 14, and 18 y from cases and controls. We calculated glyphosate residue concentrations: []. We estimated the amount of agricultural-use glyphosate applied within a radius of every residence from pregnancy to age 5 y for the full cohort using California Pesticide Use Reporting data. We assessed liver transaminases and metabolic syndrome at 18 y of age.

RESULTS

Urinary AMPA at age 5 y was associated with elevated transaminases [relative risk (RR) per , 95% confidence interval (CI): 1.06, 1.53] and metabolic syndrome (, 95% CI: 1.38, 3.11). Urinary AMPA and glyphosate residues at age 14 y were associated with metabolic syndrome [ (95% CI: 1.10, 2.93) and (95% CI: 1.03, 3.42), respectively]. Overall, a 2-fold increase in urinary AMPA during childhood was associated with a 14% and a 55% increased risk of elevated liver transaminases and metabolic syndrome, respectively. Living near agricultural glyphosate applications during early childhood (birth to 5 y of age) was also associated with metabolic syndrome at age 18 y in the case-control group (, 95% CI: 1.16, 2.02).

DISCUSSION

Childhood exposure to glyphosate and AMPA may increase risk of liver and cardiometabolic disorders in early adulthood, which could lead to more serious diseases later in life. https://doi.org/10.1289/EHP11721.

摘要

背景

肝脏疾病和代谢综合征在年轻人中的发病率有所增加。草甘膦是世界上使用最广泛的除草剂，它可能导致这些疾病的发生。

目的

我们旨在评估一生中接触草甘膦及其降解产物氨甲基膦酸（AMPA）是否与年轻人肝转氨酶升高和代谢综合征有关。

方法

我们进行了一项前瞻性队列研究（母子对子研究）和一项嵌套病例对照研究（肝转氨酶升高的病例和 91 名对照），使用来自萨利纳斯母婴健康评估中心（CHAMACOS）的数据。我们在病例和对照者怀孕期间以及儿童 5、14 和 18 岁时收集尿液样本，测量其中的草甘膦和 AMPA 浓度。我们计算了草甘膦残留浓度：[].我们使用加利福尼亚州农药使用报告数据，估算了从怀孕到 5 岁时每个居住地周围范围内应用的农业用草甘膦数量。我们在 18 岁时评估了肝转氨酶和代谢综合征。

结果

5 岁时的尿液 AMPA 与转氨酶升高相关[每增加，95%置信区间（CI）：1.06，1.53]和代谢综合征（，95% CI：1.38，3.11）。14 岁时的尿液 AMPA 和草甘膦残留与代谢综合征有关[（95% CI：1.10，2.93）和（95% CI：1.03，3.42）]。总的来说，儿童期尿液 AMPA 增加两倍，肝转氨酶升高和代谢综合征的风险分别增加 14%和 55%。在病例对照组中，儿童早期（出生至 5 岁）接触农业草甘膦也与 18 岁时的代谢综合征有关（，95% CI：1.16，2.02）。