Dong Yu, Li Yuan, Ma Liwen, Shu Shuge, Ren Jiawen, Yu Xiangyu, Luo Dan, Duan Zhizhou, Yu Yongquan
Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210000, China.
Department of Cosmetic Dermatology, The Fifth People's Hospital of Hainan Province, Haikou 570000, China.
Toxics. 2024 Aug 18;12(8):600. doi: 10.3390/toxics12080600.
Widespread glyphosate contamination in the environment and its endocrine-disrupting potential are concerning. However, evidence of glyphosate's effects on glycemic health is limited. To examine the association between glyphosate and glucose homeostasis in the general US population, a total of 3038 individuals were enrolled from the 2013-2016 cycles of the National Health and Nutrition Examination Survey (NHANES). Survey-weighted linear regression and restricted cubic spline curves were used to detect the associations between glyphosate and glycemic disorders. The effects of interactions between sex hormones and glyphosate on glycemic outcomes were evaluated. The results showed that glyphosate was significantly linked to increased glycated hemoglobin A1c (HbA1c) levels ( = 0.01; 95%CI, 0.01 to 0.02; = 0.001) and the compromised homeostatic model assessment of beta-cell function (HOMA-beta) scores ( = -0.09; 95%CI, -0.17 to -0.01; = 0.024). More importantly, these "glyphosate-glycemic disorder" associations were significantly modified by sex hormone-binding globulin (SHBG; for interaction < 0.05), with more pronounced relationships being identified in individuals with low SHBG levels. Our findings indicate that glyphosate is correlated with glucose dyshomeostasis. Individuals with low SHBG levels exhibited susceptibility to glyphosate-related glycemic toxicity; therefore, it might be prudent to determine glycemic health in those subjects with glyphosate exposure.
环境中广泛存在的草甘膦污染及其潜在的内分泌干扰作用令人担忧。然而，草甘膦对血糖健康影响的证据有限。为了研究美国普通人群中草甘膦与葡萄糖稳态之间的关联，从2013 - 2016年国家健康与营养检查调查（NHANES）周期中总共招募了3038名个体。采用调查加权线性回归和受限立方样条曲线来检测草甘膦与血糖紊乱之间的关联。评估了性激素与草甘膦之间的相互作用对血糖结果的影响。结果显示，草甘膦与糖化血红蛋白A1c（HbA1c）水平升高显著相关（β = 0.01；95%置信区间，0.01至0.02；P = 0.001），并且与β细胞功能的稳态模型评估（HOMA-β）得分受损相关（β = -0.09；95%置信区间，-0.17至-0.01；P = 0.024）。更重要的是，这些“草甘膦 - 血糖紊乱”关联受到性激素结合球蛋白（SHBG；相互作用的P < 0.05）的显著影响，在SHBG水平较低的个体中发现了更明显的关系。我们的研究结果表明，草甘膦与葡萄糖稳态失调相关。SHBG水平低的个体对草甘膦相关的血糖毒性表现出易感性；因此，对于那些接触草甘膦的受试者，确定其血糖健康状况可能是谨慎的做法。
