Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Virchows Arch. 2024 Jan;484(1):147-150. doi: 10.1007/s00428-023-03522-9. Epub 2023 Mar 1.
In general, endometrioid-defining features such as squamoid morular metaplasia are not thought to be associated with mesonephric adenocarcinoma (MA) and mesonephric-like adenocarcinoma (MLA). Here, we report a case of FGFR2-mutated ovarian MLA with squamoid morular metaplasia accompanied by aberrant nuclear and cytoplasmic β-catenin expression and CTNNB1 mutation. Histologically, the tumor showed classical MLA histology, including well-formed glands with intraluminal eosinophilic secretions and cells with papillary thyroid carcinoma-like nuclei. Squamoid morular metaplasia was intimately associated with the tumor. Glandular epithelial elements, including those immediately associated with the squamoid morules, were negative for ER, but positive for both GATA3 and PAX8; aberrant β-catenin expression was limited to the squamoid morules. This case illustrates the ability of mesonephric neoplasia to exhibit histological features previously thought to be restricted to an endometrioid phenotype.
一般来说，不认为具有典型子宫内膜样特征的如鳞形细胞芽状化生与中肾腺癌（MA）和中肾样腺癌（MLA）有关。在此，我们报告了一例伴有鳞形细胞芽状化生的 FGFR2 突变性卵巢 MLA，伴有异常核和细胞质β-catenin 表达和 CTNNB1 突变。组织学上，肿瘤显示出典型的 MLA 组织学特征，包括具有腔内嗜酸性分泌物的形成良好的腺体和具有甲状腺癌样核的细胞。鳞形细胞芽状化生与肿瘤密切相关。包括与鳞形细胞芽状结构直接相关的腺体上皮成分，均为 ER 阴性，但均为 GATA3 和 PAX8 阳性；异常的β-catenin 表达仅限于鳞形细胞芽状结构。该病例说明了中肾性肿瘤具有表现出以前认为仅限于子宫内膜样表型的组织学特征的能力。
