宫颈中肾管腺癌伴新型 FGFR2 突变。
Cervical Mesonephric Adenocarcinoma With Novel FGFR2 Mutation.
出版信息
Int J Gynecol Pathol. 2020 Sep;39(5):452-455. doi: 10.1097/PGP.0000000000000627.
PMID:31335448
Abstract
Mesonephric adenocarcinoma is a rare tumor, accounting for <1% of cervical cancers. Well-differentiated mesonephric adenocarcinoma can be difficult to distinguish from diffuse mesonephric hyperplasia. Herein, we report a case of well-differentiated mesonephric adenocarcinoma with an FGFR2 mutation not previously reported in the literature. Nonselective tyrosine kinase inhibitors or FGFR2 inhibitors may represent options for targeted therapy.
摘要
中肾腺癌是一种罕见的肿瘤，占宫颈癌的比例<1%。分化良好的中肾腺癌很难与弥漫性中肾增生区分。本文报告一例文献中未曾报道过的 FGFR2 基因突变的分化良好的中肾腺癌。非选择性酪氨酸激酶抑制剂或 FGFR2 抑制剂可能是靶向治疗的选择。
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