Villatoro Tatiana M, Mardekian Stacey K
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
Case Rep Pathol. 2018 Sep 13;2018:8741017. doi: 10.1155/2018/8741017. eCollection 2018.
Sinonasal non-intestinal-type adenocarcinoma (non-ITAC) is a rare, morphologically diverse neoplasm of the head and neck. Squamoid morular metaplasia has recently been reported as an occasional finding in non-ITAC. Interestingly, these squamoid morules often show aberrant expression of CDX2 as well as nuclear expression of -catenin, similar to other tumors that show this type of metaplasia, but the underlying mechanism responsible for this finding is not completely understood. We present two cases of low-grade non-ITAC with squamoid morules coexpressing CDX2 and nuclear -catenin by immunohistochemistry, both of which were found to harbor a mutation in , the gene encoding -catenin. This finding provides support that an alteration in the -catenin pathway, including mutations in the -catenin gene itself, is responsible for this recently described morphologic phenomenon in non-ITAC.
鼻窦非肠型腺癌（non-ITAC）是一种罕见的、形态多样的头颈部肿瘤。最近有报道称，在non-ITAC中偶尔会发现鳞状桑葚样化生。有趣的是，这些鳞状桑葚体常常显示CDX2异常表达以及β-连环蛋白核表达，这与其他显示这种化生类型的肿瘤相似，但导致这一发现的潜在机制尚未完全明确。我们报告了2例低级别non-ITAC病例，其鳞状桑葚体通过免疫组化共表达CDX2和β-连环蛋白核，二者均被发现存在β-连环蛋白编码基因CTNNB1的突变。这一发现支持了β-连环蛋白信号通路的改变，包括β-连环蛋白基因本身的突变，是导致non-ITAC中最近描述的这种形态学现象的原因。
