Department of Endodontics, Faculty of Dentistry, Kocaeli University, Kocaeli, Turkey.
Department of Endodontics, Faculty of Dentistry, Zonguldak Bülent Ecevit University, Zonguldak, Turkey.
Clin Oral Investig. 2023 Jun;27(6):3189-3196. doi: 10.1007/s00784-023-04930-6. Epub 2023 Mar 1.
This randomized clinical trial aimed to evaluate the effect of two rotaries (ProTaper Universal Retreatment (PTUR)), D-Race (DR) + XP-Endo Finisher R (XPFR) and one reciprocating (Reciproc Blue (RB) retreatment techniques on the release of neuropeptides (Substance P, calcitonin gene-related peptide (CGRP)), and cytokines (IL-6 and IL-10) in periapical fluid in root canal retreatment of single-rooted teeth.
In this randomized clinical trial (ClinicalTrials.gov ID: NCT05039502), seventy-five patients scheduled for retreatment were randomly divided into 3 groups according to the file system used to remove root canal filling materials (n = 25): PTUR, RB, and DR + XPFR. After reshaping and disinfection of the root canals, periapical fluid samples were taken, and the levels of Substance P, CGRP, IL-6, and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA) test. Data were analyzed using the Kruskal-Wallis and chi-square tests. The level of significance was set as p = 0. 05.
All the allocated participants received the intervention and were analyzed. There was no statistically significant difference among groups in terms of gender, age, tooth localization, and the distribution of analgesic use after treatment (p values 0.799, 0.095, 0.637, 1.000, respectively). No statistically significant difference was found in terms of the levels of Substance P, CGRP, and IL-10 among groups (p > .05), except IL-6.
PTUR, RB, and DR + XPFR files have comparable results in the expression of inflammatory mediators.
Retreatment files powered with rotary or reciprocating motion produced similar neuropeptide and cytokine levels in patients.
本随机临床试验旨在评估两种旋转器械（ProTaper Universal Retreatment (PTUR)、D-Race (DR) + XP-Endo Finisher R (XPFR)）和一种往复运动器械（Reciproc Blue (RB)）在根管再治疗中单根牙根尖区神经肽（P 物质、降钙素基因相关肽 (CGRP)）和细胞因子（IL-6 和 IL-10）释放方面的效果。
在这项随机临床试验（ClinicalTrials.gov ID：NCT05039502）中，根据用于去除根管充填材料的文件系统，将 75 名计划进行再治疗的患者随机分为 3 组（n = 25）：PTUR、RB 和 DR + XPFR。在根管重塑和消毒后，采集根尖区液样本，并用酶联免疫吸附试验（ELISA）检测 P 物质、CGRP、IL-6 和 IL-10 的水平。数据采用 Kruskal-Wallis 和卡方检验进行分析。显著性水平设为 p = 0.05。
所有分配的参与者均接受了干预并进行了分析。在性别、年龄、牙齿定位以及治疗后镇痛药物使用分布方面，各组之间无统计学差异（p 值分别为 0.799、0.095、0.637 和 1.000）。各组间 P 物质、CGRP 和 IL-10 水平无统计学差异（p > 0.05），但 IL-6 除外。
PTUR、RB 和 DR + XPFR 锉在表达炎症介质方面具有相似的结果。
旋转或往复运动的再治疗锉在患者中产生了相似的神经肽和细胞因子水平。
