通过 SAr 步骤实现聚氟芳基硫醚的克级规模合成的方案。
A protocol for the gram-scale synthesis of polyfluoroaryl sulfides via an SAr step.
机构信息
Department of Chemistry, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
出版信息
STAR Protoc. 2023 Mar 17;4(1):102043. doi: 10.1016/j.xpro.2023.102043. Epub 2023 Jan 19.
Polyfluoroaryl sulfide is one of the prevalent motifs ubiquitous in materials and pharmaceutical chemistry. We herein describe a simple yet efficient procedure for their synthesis from readily available thiols and polyfluoroarenes via an SAr step. We detail specific steps for a gram-scale preparation of 2-((perfluoropyridin-4-yl)thio)benzo[d]thiazole 3 from mercaptobenzothiazole 1 and pentafluoropyridine 2. For complete details on the use and execution of this protocol, please refer to Liao et al. (2022)..
多氟芳基硫醚是材料和药物化学中普遍存在的结构基序之一。本文描述了一种简单而有效的方法，通过 SAr 步骤，由易得的硫醇和多氟芳烃来合成它们。我们详细介绍了从巯基苯并噻唑 1 和五氟吡啶 2 制备 2-((全氟吡啶-4-基)硫代)苯并[d]噻唑 3 的克级规模制备的具体步骤。有关此方案的使用和执行的详细信息，请参阅 Liao 等人（2022 年）。
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