从正常人和囊性纤维化患者的人类诱导多能干细胞生成肺离子细胞。 - Suppr

Generation of Pulmonary Ionocytes from Normal and Cystic Fibrosis Human Induced Pluripotent Stem Cells.

作者信息

Wang Ruobing, Simone-Roach Chantelle, Lindstrom-Vautrin Jonathan, Wang Feiya, Rollins Stuart, Bawa Pushpinder Singh, Lu Junjie, Tang Yang, Beermann Mary Lou, Schlaeger Thorsten, Mahoney John, Rowe Steven M, Hawkins Finn J, Kotton Darrell N

机构信息

Division of Pulmonary Medicine, Boston Children's Hospital, Boston, Massachusetts.

Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, Massachusetts.

出版信息

Am J Respir Crit Care Med. 2023 May 1;207(9):1249-1253. doi: 10.1164/rccm.202205-1010LE.

DOI:10.1164/rccm.202205-1010LE

PMID:36857488

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10161739/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/809e/10161739/d5e42d936dd6/rccm.202205-1010LEf1.jpg

相似文献

Generation of Pulmonary Ionocytes from Normal and Cystic Fibrosis Human Induced Pluripotent Stem Cells.从正常人和囊性纤维化患者的人类诱导多能干细胞生成肺离子细胞。

Am J Respir Crit Care Med. 2023 May 1;207(9):1249-1253. doi: 10.1164/rccm.202205-1010LE.

Modeling Cystic Fibrosis Using Pluripotent Stem Cell-Derived Human Pancreatic Ductal Epithelial Cells.使用多能干细胞衍生的人胰腺导管上皮细胞建立囊性纤维化模型。

Stem Cells Transl Med. 2016 May;5(5):572-9. doi: 10.5966/sctm.2015-0276. Epub 2016 Mar 31.

In vitro platform to model the function of ionocytes in the human airway epithelium.体外平台模拟人类气道上皮细胞中的离子细胞功能。

Respir Res. 2024 Apr 25;25(1):180. doi: 10.1186/s12931-024-02800-7.

Generation of two induced pluripotent stem cell lines (RCMGi005-A/B) from human skin fibroblasts of a cystic fibrosis patient with homozygous F508del mutation in CFTR gene.从囊性纤维化患者的同源 F508del 突变 CFTR 基因突变的人皮肤成纤维细胞中生成两个诱导多能干细胞系（RCMGi005-A/B）。

Stem Cell Res. 2022 Oct;64:102896. doi: 10.1016/j.scr.2022.102896. Epub 2022 Aug 18.

Ionocytes and CFTR Chloride Channel Expression in Normal and Cystic Fibrosis Nasal and Bronchial Epithelial Cells.正常和囊性纤维化鼻和支气管上皮细胞中的离子细胞和 CFTR 氯离子通道表达。

Cells. 2020 Sep 13;9(9):2090. doi: 10.3390/cells9092090.

Generation of an induced pluripotent stem cell line (IGGi002A) from nasal cells of a cystic fibrosis patient homozygous for the G542X-CFTR mutation.从一位 G542X-CFTR 突变纯合的囊性纤维化患者的鼻腔细胞中诱导生成多能干细胞系（IGGi002A）。

Stem Cell Res. 2023 Oct;72:103232. doi: 10.1016/j.scr.2023.103232. Epub 2023 Oct 18.

Generation of an induced pluripotent stem cell line (MHHi018-A) from a patient with Cystic Fibrosis carrying p.Asn1303Lys (N1303K) mutation.从一名携带p.Asn1303Lys（N1303K）突变的囊性纤维化患者中生成诱导多能干细胞系（MHHi018-A）。

Stem Cell Res. 2020 Apr;44:101744. doi: 10.1016/j.scr.2020.101744. Epub 2020 Mar 25.

Targeted correction and restored function of the CFTR gene in cystic fibrosis induced pluripotent stem cells.靶向纠正囊性纤维化诱导多能干细胞中的 CFTR 基因并恢复其功能。

Stem Cell Reports. 2015 Apr 14;4(4):569-77. doi: 10.1016/j.stemcr.2015.02.005. Epub 2015 Mar 12.

Generation of induced pluripotent stem cell line (RCMGi008-A) from human skin fibroblasts of a cystic fibrosis patient with compound heterozygous F508del/CFTRdele2.3 mutations in CFTR gene.从囊性纤维化患者的皮肤成纤维细胞中诱导生成多能干细胞系（RCMGi008-A），该患者 CFTR 基因中存在复合杂合 F508del/CFTRdele2.3 突变。

Stem Cell Res. 2022 Aug;63:102854. doi: 10.1016/j.scr.2022.102854. Epub 2022 Jul 7.

Personalized medicine for cystic fibrosis: establishing human model systems.囊性纤维化的个性化医疗：建立人类模型系统。

Pediatr Pulmonol. 2015 Oct;50 Suppl 40:S14-23. doi: 10.1002/ppul.23233.

引用本文的文献

An in vitro model of the epithelial airway reveals a key function for EHF in lung homeostasis and disease.上皮气道的体外模型揭示了EHF在肺稳态和疾病中的关键作用。

Dis Model Mech. 2025 Jun 1;18(6). doi: 10.1242/dmm.052106. Epub 2025 Jul 1.

Induced Pluripotent (iPSC) and Mesenchymal (MSC) Stem Cells for In Vitro Disease Modeling and Regenerative Medicine.用于体外疾病建模和再生医学的诱导多能干细胞（iPSC）和间充质干细胞（MSC）

Int J Mol Sci. 2025 Jun 11;26(12):5617. doi: 10.3390/ijms26125617.

Do pulmonary ionocytes absorb chloride or secrete chloride?肺离子细胞是吸收氯离子还是分泌氯离子？

Am J Physiol Cell Physiol. 2025 Feb 1;328(2):C400-C403. doi: 10.1152/ajpcell.00672.2024. Epub 2024 Dec 23.

From Epithelium to Therapy: Transitional Cells in Lung Fibrosis.从上皮细胞到治疗：肺纤维化中的过渡细胞

Am J Respir Cell Mol Biol. 2025 May;72(5):472-483. doi: 10.1165/rcmb.2024-0372TR.

Building a human lung from pluripotent stem cells to model respiratory viral infections.从多能干细胞构建人类肺脏以模拟呼吸道病毒感染。

Respir Res. 2024 Jul 15;25(1):277. doi: 10.1186/s12931-024-02912-0.

In vitro platform to model the function of ionocytes in the human airway epithelium.体外平台模拟人类气道上皮细胞中的离子细胞功能。

Respir Res. 2024 Apr 25;25(1):180. doi: 10.1186/s12931-024-02800-7.

Human Airway and Alveolar Organoids from BAL Fluid.来自支气管肺泡灌洗（BAL）液的人呼吸道和肺泡类器官

Am J Respir Crit Care Med. 2024 Jun 15;209(12):1501-1504. doi: 10.1164/rccm.202310-1831LE.

Functional Consequences of CFTR Interactions in Cystic Fibrosis.囊性纤维化中 CFTR 相互作用的功能后果。

Int J Mol Sci. 2024 Mar 16;25(6):3384. doi: 10.3390/ijms25063384.

Cell Type Catalog of Middle Turbinate Epithelium ().中鼻甲上皮细胞类型目录（）。

OTO Open. 2023 Dec 13;7(4):e91. doi: 10.1002/oto2.91. eCollection 2023 Oct-Dec.

Macrophages and stem/progenitor cells interplay in adipose tissue and skeletal muscle: a review.巨噬细胞与脂肪组织和骨骼肌中的干细胞/祖细胞相互作用：综述

Stem Cell Investig. 2023 Apr 13;10:9. doi: 10.21037/sci-2023-009. eCollection 2023.

本文引用的文献

A reference human induced pluripotent stem cell line for large-scale collaborative studies.一个用于大规模合作研究的参考性人诱导多能干细胞系。

Cell Stem Cell. 2022 Dec 1;29(12):1685-1702.e22. doi: 10.1016/j.stem.2022.11.004.

Notch activation during early mesoderm induction modulates emergence of the T/NK cell lineage from human iPSCs.Notch 激活在早期中胚层诱导过程中调节人诱导多能干细胞向 T/NK 细胞谱系的出现。

Stem Cell Reports. 2022 Dec 13;17(12):2610-2628. doi: 10.1016/j.stemcr.2022.10.007. Epub 2022 Nov 3.

Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia.分泌细胞在人气道表面上皮的气道CFTR表达和功能中占主导地位。

Am J Respir Crit Care Med. 2021 May 15;203(10):1275-1289. doi: 10.1164/rccm.202008-3198OC.

A molecular cell atlas of the human lung from single-cell RNA sequencing.人类肺部单细胞 RNA 测序的分子细胞图谱。

Nature. 2020 Nov;587(7835):619-625. doi: 10.1038/s41586-020-2922-4. Epub 2020 Nov 18.

Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells.气道基底干细胞的人多能干细胞起源。

Cell Stem Cell. 2021 Jan 7;28(1):79-95.e8. doi: 10.1016/j.stem.2020.09.017. Epub 2020 Oct 23.

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis.单细胞 RNA 测序揭示了肺纤维化中不同上皮和间充质谱系的促纤维化作用。

Sci Adv. 2020 Jul 8;6(28):eaba1972. doi: 10.1126/sciadv.aba1972. eCollection 2020 Jul.

Single-Cell Reconstruction of Human Basal Cell Diversity in Normal and Idiopathic Pulmonary Fibrosis Lungs.单细胞重建正常和特发性肺纤维化肺中基底细胞多样性。

Am J Respir Crit Care Med. 2020 Dec 1;202(11):1540-1550. doi: 10.1164/rccm.201904-0792OC.

A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte.气道上皮细胞的单细胞图谱揭示了富含 CFTR 的肺离子细胞。

Nature. 2018 Aug;560(7718):377-381. doi: 10.1038/s41586-018-0394-6. Epub 2018 Aug 1.

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes.一个经过修正的气道上皮细胞层级结构包含 CFTR 表达的离子细胞。

Nature. 2018 Aug;560(7718):319-324. doi: 10.1038/s41586-018-0393-7. Epub 2018 Aug 1.

Notch-dependent differentiation of adult airway basal stem cells.Notch 依赖性分化的成年气道基底干细胞。

Cell Stem Cell. 2011 Jun 3;8(6):639-48. doi: 10.1016/j.stem.2011.04.003.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Generation of Pulmonary Ionocytes from Normal and Cystic Fibrosis Human Induced Pluripotent Stem Cells.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献

本文引用的文献