Bindi A, Russo G, Benvenuti F, Bandinelli S, Ferrucci L, Rossi L
II Clinica Neurologica, Università, Firenze.
Riv Neurol. 1987 Jul-Aug;57(4):245-50.
In 14 untreated informed patients (5 M, 9 F, mean age 62 yrs) with initial idiopathic Parkinson's disease AEPs, early (BAEPs) and long latency components (LLCs) were studied. In 10 subjects experimental session were carried out before treatment (L-Dopa plus Carbidopa, 0.25-0.50 g/die) and at 2, 6 and 12 months intervals. At the same time all patients underwent clinical assessment by Webster Rating Scale evaluation. BAEPs. The IPLs prolonged (greater than 2.5 SD) in 6 patients: in 3 the III-V, in 2 the I-V and in 1 the I-III. The absolute latencies were abnormally prolonged in 11 subjects: V wave in 4, III wave in 3, II wave in 2 and I wave in 3. The absence of one or more components were observed in 12 out of 14 patients, the most frequently absent was the II wave (12 patients). LLCs. The absolute latencies of P1 and N1 waves were prolonged respectively in 4 and in 3 subjects. The P1-N1 IPL was prolonged only in one patient. A follow-up study demonstrated transitory improvement of the AEPs previously observed abnormalities. The improvement was partially in agreement with clinical assessment.
在14例未经治疗的、已被告知情况的特发性帕金森病AEP患者（5例男性，9例女性，平均年龄62岁）中，对早期（脑干听觉诱发电位，BAEPs）和长潜伏期成分（LLCs）进行了研究。在10名受试者中，在治疗前（左旋多巴加卡比多巴，0.25 - 0.50 g/天）以及治疗后2、6和12个月时进行了实验。同时，所有患者均通过韦伯斯特评分量表评估进行临床评估。BAEPs。6例患者的峰间潜伏期延长（大于2.5个标准差）：3例为Ⅲ - Ⅴ波，2例为Ⅰ - Ⅴ波，1例为Ⅰ - Ⅲ波。11名受试者的绝对潜伏期异常延长：Ⅴ波4例，Ⅲ波3例，Ⅱ波2例，Ⅰ波3例。14例患者中有12例观察到一个或多个成分缺失，最常缺失的是Ⅱ波（12例患者）。LLCs。P1波和N1波的绝对潜伏期分别在4例和3例受试者中延长。P1 - N1峰间潜伏期仅在1例患者中延长。一项随访研究表明，先前观察到的AEP异常有短暂改善。这种改善部分与临床评估一致。
