Cosi V, Romani A, Callieco R, Zerbi F
Boll Soc Ital Biol Sper. 1984 Mar 30;60(3):603-9.
Visual evoked potentials by flash (VEP-f) and pattern reversal (VEP-p) stimulation and BAEPs were performed in parkinsonian patients before and after 1 and 4 hours levodopa + Carbidopa administration in two separate experiments. In the first experiment (9 patients and 9 controls) an increase of latencies of peaks III and IV of VEP-f was observed in parkinsonian patients but not in controls. In the second experiment (6 patients) an increase of latencies of peaks N70 and P100 of VEP-p and an increase of latency of peak III and of III-V interval of BAEPs was observed. The results confirm the influence of dopaminergic systems on visual pathways and suggest that the effects of acute 1-DOPA administration may differ from those of chronic treatment. Moreover some evidence exists that dopaminergic systems are involved also in acoustic pathways.
在两项独立实验中，对帕金森病患者在服用左旋多巴+卡比多巴1小时和4小时前后进行了闪光视觉诱发电位（VEP-f）、图形翻转视觉诱发电位（VEP-p）刺激以及脑干听觉诱发电位（BAEP）检测。在第一个实验（9名患者和9名对照）中，观察到帕金森病患者VEP-f的峰III和峰IV潜伏期增加，而对照组未出现这种情况。在第二个实验（6名患者）中，观察到VEP-p的N70和P100峰潜伏期增加，以及BAEP的峰III潜伏期和III-V间期增加。结果证实了多巴胺能系统对视觉通路的影响，并表明急性服用左旋多巴的效果可能与慢性治疗不同。此外，有证据表明多巴胺能系统也参与听觉通路。
