Department of Biomedicine and Medical Diagnostics, School of Science, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand. Electronic address: ronan.o'
Department of Rural Clinical Sciences, La Trobe Rural Health School, La Trobe University, Victoria, Australia.
Res Microbiol. 2023 May;174(4):104046. doi: 10.1016/j.resmic.2023.104046. Epub 2023 Feb 27.
Enterococcus faecium is a major species in infections by vancomycin-resistant enterococci (VRE). New variants of the pathogen have emerged and become dominant in healthcare settings. Two such examples, vanB ST796 and vanA ST1421 sequence types, originally arose in Australia and proceeded to cause VRE outbreaks in other countries. Of concern is the detection in Europe of vancomycin variable enterococci (VVE) belonging to ST1421 that exhibit a vancomycin-susceptible phenotype but can revert to resistant in the presence of vancomycin. The recent application of genome sequencing for increasing our understanding of the evolution and spread of VRE is also explored here.
屎肠球菌是耐万古霉素肠球菌（VRE）感染的主要菌种。该病原体的新变种已经出现，并在医疗保健环境中占据主导地位。其中两个例子，vanB ST796 和 vanA ST1421 序列类型，最初出现在澳大利亚，随后在其他国家引发了 VRE 爆发。令人担忧的是，在欧洲检测到属于 ST1421 的万古霉素可变肠球菌（VVE），其表现出对万古霉素敏感的表型，但在存在万古霉素的情况下可恢复为耐药性。本文还探讨了最近应用基因组测序来增加我们对 VRE 进化和传播的理解。
