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Covid-19 是自身免疫性和多种炎症性疾病的诱发因素。

Covid-19 a triggering factor of autoimmune and multi-inflammatory diseases.

机构信息

Department of Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom.

Faculty of Pharmacy, University of Modern Sciences - CKM, Mostar 88000, Bosnia and Herzegovina.

出版信息

Life Sci. 2023 Apr 15;319:121531. doi: 10.1016/j.lfs.2023.121531. Epub 2023 Feb 27.

DOI:10.1016/j.lfs.2023.121531
PMID:36858313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9969758/
Abstract

SARS-CoV-2 virus has attracted a lot of attention globally due to the autoimmune and inflammatory processes that were observed during the development of Covid-19 disease. Excessive activation of immune response and triggering of autoantibodies synthesis as well as an excessive synthesis of inflammatory cytokines and the onset of cytokine storm has a vital role in the disease outcome and the occurring autoimmune complications. This scenario is reminiscent of infiltration of lymphocytes and monocytes in specific organs and the increased production of autoantibodies and chemoattractants noted in other inflammatory and autoimmune diseases. The main goal of this study is to investigate the complex inflammatory processes that occur in Covid-19 disease and to find similarities with other inflammatory diseases such as multiple sclerosis (MS), acute respiratory distress syndrome (ARDS), rheumatoid arthritis (RA) and Kawasaki syndrome to advance existing diagnostic and therapeutic protocols. The therapy with Interferon-gamma (IFN-γ) and the use of S1P receptor modulators showed promising results. However, there are many unknowns about these mechanisms and possible novel therapies. Therefore, the inflammation and autoimmunity triggered by Covid-19 should be further investigated to improve existing diagnostic procedures and therapeutic protocols for Covid-19.

摘要

由于在 COVID-19 疾病发展过程中观察到的自身免疫和炎症过程，SARS-CoV-2 病毒在全球引起了广泛关注。过度激活免疫反应和触发自身抗体合成以及过度合成炎症细胞因子和细胞因子风暴在疾病结局和发生的自身免疫并发症中起着至关重要的作用。这种情况让人联想到淋巴细胞和单核细胞在特定器官中的浸润，以及在其他炎症性和自身免疫性疾病中观察到的自身抗体和趋化因子的产生增加。本研究的主要目的是研究 COVID-19 疾病中发生的复杂炎症过程，并寻找与其他炎症性疾病（如多发性硬化症 (MS)、急性呼吸窘迫综合征 (ARDS)、类风湿关节炎 (RA) 和川崎病）的相似之处，以推进现有的诊断和治疗方案。干扰素-γ (IFN-γ) 的治疗和 S1P 受体调节剂的使用显示出有希望的结果。然而，这些机制和可能的新疗法仍有许多未知之处。因此，应进一步研究 COVID-19 引发的炎症和自身免疫，以改进 COVID-19 的现有诊断程序和治疗方案。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b024/9969758/1646db1f68dc/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b024/9969758/4aed04090ac6/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b024/9969758/8c6d49503ee1/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b024/9969758/3c76120fa344/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b024/9969758/3d37153e74d4/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b024/9969758/4dc59bcc9dc3/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b024/9969758/be83a2034c7e/gr7_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b024/9969758/d7246dfe2b73/gr8_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b024/9969758/1b67189ae278/gr9_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b024/9969758/397a90be8837/gr10_lrg.jpg
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