特比萘芬耐药的堇毛癣菌和红色毛癣菌的日本分离株的体外唑类药物敏感性试验。
In vitro Azole Susceptibility Testing of Japanese Isolates of Terbinafine-Resistant Trichophyton indotineae and Trichophyton rubrum.
机构信息
Department of Dermatology, Tokyo Medical University.
Teikyo University Institute of Medical Mycology (TIMM).
出版信息
Med Mycol J. 2023;64(1):23-25. doi: 10.3314/mmj.22-00021.
Multi-antifungal-resistant strains of Trichophyton indotineae and Trichophyton rubrum have been isolated in Japan. In the present study, we examined the in vitro susceptibility of terbinafine (TRBF) -resistant isolates of T. indotineae and T. rubrum to efinaconazole (EFCZ) and luliconazole (LUCZ). In all isolates, the minimum inhibitory concentrations were ≥ 32 mg/l for TRBF, < 0.03 to 16 mg/l for itraconazole, < 0.03 to 16 mg/l for ravuconazole, < 0.03 to 0.5 mg/l for LUCZ, and < 0.03 to 4 mg/l for EFCZ. Of note, T. rubrum NUBS21012 and T. indotineae NUBS 19006 showed resistance to LUCZ and/or EFCZ unlike the other isolates.
在日本已经分离到了耐多种抗真菌药物的须癣毛癣菌和红色毛癣菌菌株。在本研究中，我们检测了特比萘芬（TRBF）耐药的须癣毛癣菌和红色毛癣菌分离株对依氟康唑（EFCZ）和卢立康唑（LUCZ）的体外敏感性。在所有分离株中，TRBF 的最低抑菌浓度均为≥32mg/L，伊曲康唑<0.03-16mg/L，伏立康唑<0.03-16mg/L，卢立康唑<0.03-0.5mg/L，依氟康唑<0.03-4mg/L。值得注意的是，与其他分离株不同，红色毛癣菌 NUBS21012 和须癣毛癣菌 NUBS 19006 对卢立康唑和/或依氟康唑表现出耐药性。
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