Enochsson L, Hellström P M, Nylander G, Johansson C
Dept. of Surgery, Karolinska Hospital, Stockholm, Sweden.
Scand J Gastroenterol. 1987 Oct;22(8):969-74. doi: 10.3109/00365528708991944.
The purpose of the present study was to analyze changes of the myoelectric activity in experimental mechanical obstruction and paralytic ileus of the small intestine. Myoelectric activity was recorded in the upper small intestine of conscious, fasted rats by three bipolar electrodes implanted 10 cm apart. In the basal state regular myoelectric motility complexes (MMCs) were registered in all experimental animals. Obstruction of the small intestine (n = 13) was produced by a ligature between the middle and distal electrodes. Proximal to the obstruction regular MMCs continued. After 45 +/- 15 min at the middle (p less than 0.01), and 85 +/- 10 min at the duodenal electrode (p less than 0.01), MMCs disappeared. Another motility pattern was established, characterized by clusters of spikes, occurring regularly with 2-min intervals, separated by short silent periods, and a rapid aboral migration (p less than 0.01). Distal to the obstruction the propagation of MMCs was immediately disrupted. After a quiescent period of 13 +/- 3 min irregular spiking occurred and continued throughout the experiment (p less than 0.01). Intraperitoneal instillation of 0.1 M hydrochloric acid (n = 8) produced a prompt and long-lasting inhibition of the MMCs. The quiescence lasted for 70 +/- 23 min, until the MMCs reappeared (p less than 0.01). It is concluded that complete intestinal obstruction is followed by a series of significant and well-defined changes of myoelectric activity on both sides of the obstruction. Nociceptive stimulation of the peritoneum produces intestinal paralysis. The immediate inhibition of the motility indicates that the paralysis is not secondary to inflammatory reactions.
本研究的目的是分析实验性小肠机械性梗阻和麻痹性肠梗阻时肌电活动的变化。通过在清醒、禁食大鼠的上段小肠植入三个相距10 cm的双极电极来记录肌电活动。在基础状态下，所有实验动物均记录到规则的肌电运动复合波（MMCs）。小肠梗阻（n = 13）通过在中间和远端电极之间结扎产生。梗阻近端的MMCs仍继续存在。在梗阻部位中间经过45±15分钟（p<0.01），十二指肠电极处经过85±10分钟（p<0.01）后，MMCs消失。另一种运动模式形成，其特征为尖峰簇，以2分钟的间隔有规律地出现，中间间隔短暂的静息期，并伴有快速的向口迁移（p<0.01）。梗阻远端MMCs的传播立即中断。经过13±3分钟的静息期后，出现不规则的尖峰，并在整个实验过程中持续存在（p<0.01）。腹腔内注入0.1 M盐酸（n = 8）可迅速且持久地抑制MMCs。静息持续70±23分钟，直到MMCs再次出现（p<0.01）。结论是，完全性肠梗阻后梗阻两侧的肌电活动会发生一系列显著且明确的变化。对腹膜的伤害性刺激会导致肠麻痹。运动的立即抑制表明麻痹并非继发于炎症反应。
