Nilsson L P, Granström G
Department of Histology, University of Gothenburg, Sweden.
Scand J Plast Reconstr Surg Hand Surg. 1987;21(2):167-74. doi: 10.3109/02844318709078096.
An experimental model was designed for the study of mandibular fracture healing in Sprague-Dawley rats. Healing and remodellation were studied by routine histology and the vascular supply of the mandible by micro-angiography. The blood supply to the body of the mandible was similar to that seen in long bones. The arterial vascular system appeared to be intimately involved with the formation of bone. The vessel configuration varied in relation to the progress of healing. The effect of heparin, dextran 40 and dextran 70 therapy to increase blood flow in the fracture region was tested. Dextrans had no effect on fracture healing whereas heparin induced an increased chondroid reaction in the callus. Serum alkaline phosphatase was measured as a marker for hard-tissue formation. The enzyme activity was reduced after fracture with a minimum activity three days after fracture.
设计了一种实验模型，用于研究斯普拉格-道利大鼠下颌骨骨折的愈合情况。通过常规组织学研究愈合和重塑过程，并通过微血管造影研究下颌骨的血管供应。下颌骨体部的血液供应与长骨相似。动脉血管系统似乎与骨的形成密切相关。血管形态随愈合进程而变化。测试了肝素、右旋糖酐40和右旋糖酐70治疗对增加骨折区域血流的效果。右旋糖酐对骨折愈合没有影响，而肝素会导致骨痂中类软骨反应增加。测量血清碱性磷酸酶作为硬组织形成的标志物。骨折后该酶活性降低，骨折后三天活性最低。
