Nilsson L P, Granström G, Röckert H O
Int J Oral Maxillofac Surg. 1987 Feb;16(1):77-89. doi: 10.1016/s0901-5027(87)80034-6.
The effect of heparin, dextran 40, dextran 70 and hyperbaric oxygen (HBO) therapy to reduce tissue damage after mandibular osteotomy was tested in an experimental system. Tissue damage was recorded morphologically and blood flow and vascular bed was determined by isotope techniques. Subcutaneously administered heparin reduced morphologically determined tissue damage in the incisor odontoblastoma, pulp and ameloblastoma. Furthermore, central and peripheral bone damage was prevented by heparin. Dextrans had no preventive effect on tissue damage. HBO treatment reduced tissue damage in a similar manner to heparin but also induced reparative events as osteodentin formation in pulps and chondroid reactions in bone. Effects on blood flow and vascular bed provided a basis for a possible role for HBO and heparin treatment in tissue damage after osteotomy.
在一个实验系统中测试了肝素、低分子右旋糖酐、中分子右旋糖酐和高压氧（HBO）疗法对减少下颌骨截骨术后组织损伤的作用。通过形态学记录组织损伤，并采用同位素技术测定血流量和血管床。皮下注射肝素可在形态学上减少切牙成牙本质细胞瘤、牙髓和成釉细胞瘤中的组织损伤。此外，肝素可预防中央和外周骨损伤。右旋糖酐对组织损伤没有预防作用。HBO治疗减少组织损伤的方式与肝素相似，但也诱导了修复过程，如牙髓中骨样牙本质的形成和骨中的软骨样反应。对血流量和血管床的影响为HBO和肝素治疗在截骨术后组织损伤中可能发挥的作用提供了依据。
