Purves D, Voyvodic J T, Magrassi L, Yawo H
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110.
Science. 1987 Nov 20;238(4830):1122-6. doi: 10.1126/science.3685967.
The distribution of presynaptic endings on the surfaces of autonomic ganglion cells was mapped in living mice after intravenous administration of a styryl pyridinium dye. The staining and imaging techniques did not appear to damage the ganglion cells, or the synapses on them; these procedures could therefore be repeated after an arbitrary period. Observations of the same neurons at intervals of up to 3 weeks indicate that the pattern of preganglionic terminals on many of these nerve cells gradually changes.
静脉注射一种苯乙烯基吡啶染料后，在活体小鼠中绘制了自主神经节细胞表面突触前末梢的分布图。染色和成像技术似乎并未损害神经节细胞或其上的突触；因此，这些操作可以在任意时间段后重复进行。对同一神经元进行长达3周的间隔观察表明，许多这些神经细胞上节前终末的模式逐渐发生变化。
