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因饮用本地生产的无标签酒精导致的致命毒性:来自尼泊尔的一组说明性病例

Fatal toxicity due to locally produced unlabeled alcohol consumption: An illustrative case series from Nepal.

作者信息

Subedi Nuwadatta, Pandey Deb P, Wagle Abhishesh, Bhandari Shankar, Paudel Sabita, Karn Mitesh

机构信息

Gandaki Medical College Teaching Hospital and Research Center, Pokhara, Gandaki Province, Nepal.

Research Center, Invention and Innovation Center (RC-II), Pokhara, Gandaki University, Gandaki Province, Nepal.

出版信息

SAGE Open Med Case Rep. 2023 Feb 24;11:2050313X231157985. doi: 10.1177/2050313X231157985. eCollection 2023.

DOI:10.1177/2050313X231157985
PMID:36860306
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9969422/
Abstract

Locally prepared liquor, which is not standardized or regulated, though cheap can contain various toxic ingredients and even may be fatal. We report a case series of four adult males who died within 18.5 h due to the effect of local liquor consumption in a hilly district of Gandaki Province of Nepal. Methanol toxicity due to illicitly produced alcohol consumption should be managed with adequate supportive care and administration of specific antidotes such as ethanol or fomepizole. Liquor production should be standardized, and quality checks should be done before the sale for consumption.

摘要

当地酿造的酒未经标准化或监管,虽然价格便宜,但可能含有各种有毒成分,甚至可能致命。我们报告了一组病例,四名成年男性在尼泊尔甘达基省一个山区饮用当地酒18.5小时内死亡。因饮用非法生产的酒精导致甲醇中毒,应给予充分的支持治疗,并使用乙醇或甲吡唑等特效解毒剂。酒类生产应标准化,销售供消费前应进行质量检查。

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本文引用的文献

1
Clinical and forensic toxicology of methanol.甲醇的临床与法医毒理学
Forensic Sci Rev. 2021 Jul;33(2):117-143.
2
Methanol poisoning as a new world challenge: A review.甲醇中毒——一项新的全球挑战:综述
Ann Med Surg (Lond). 2021 Jun 2;66:102445. doi: 10.1016/j.amsu.2021.102445. eCollection 2021 Jun.
3
Consensus statements on the approach to patients in a methanol poisoning outbreak.甲醇中毒暴发事件中患者处理方法的共识声明。
Clin Toxicol (Phila). 2019 Dec;57(12):1129-1136. doi: 10.1080/15563650.2019.1636992. Epub 2019 Jul 22.
4
Association between acute methanol poisoning and subsequent mortality: a nationwide study in Taiwan.急性甲醇中毒与后续死亡率的关系:台湾的全国性研究。
BMC Public Health. 2018 Aug 7;18(1):985. doi: 10.1186/s12889-018-5918-3.
5
Recommendations for the role of extracorporeal treatments in the management of acute methanol poisoning: a systematic review and consensus statement.体外治疗在急性甲醇中毒管理中的作用推荐:系统评价和共识声明。
Crit Care Med. 2015 Feb;43(2):461-72. doi: 10.1097/CCM.0000000000000708.
6
American Academy of Clinical Toxicology practice guidelines on the treatment of methanol poisoning.美国临床毒理学学会甲醇中毒治疗实践指南
J Toxicol Clin Toxicol. 2002;40(4):415-46. doi: 10.1081/clt-120006745.
7
Methyl alcohol poisoning: an autopsy study of 28 cases.甲醇中毒:28例尸检研究
J Postgrad Med. 1991 Jan;37(1):9-13.