Coppin C M
Division of Medical Oncology, University of British Columbia, Vancouver, Canada.
Semin Oncol. 1987 Dec;14(4 Suppl 4):34-42.
Delivered and planned drug doses in chemotherapy trials are analyzed in relation to dose size, dose rate, and total drug delivery. Time-dose factors are presented in different ways, further exploring what may be misleading when comparing one treatment program with another. The time frame over which treatment intensity is to be calculated is recognized as arbitrary and not necessarily from start to end of treatment. Considerations for doses missed are presented. The cumulative-dose plot represents a new method of data presentation. This method graphically captures both intensity and total drug delivery per patient, and is helpful when analyzing trials designed to isolate treatment variables and improve the therapeutic index of available drugs.
对化疗试验中已给药和计划给药剂量进行分析，涉及剂量大小、剂量率和总药物输送量。时间 - 剂量因素以不同方式呈现，进一步探讨在比较不同治疗方案时可能产生误导的因素。计算治疗强度的时间范围被认为是任意的，不一定是从治疗开始到结束。文中还给出了对漏服剂量的考量。累积剂量图代表了一种新的数据呈现方法。这种方法以图形方式反映了每位患者的治疗强度和总药物输送量，在分析旨在分离治疗变量并提高现有药物治疗指数的试验时很有帮助。
