Dymarskiĭ L Iu, Sanchakova A V, Aleksandrova G I, Trishkina E A
Vopr Onkol. 1984;30(6):67-73.
Adriamycin (alone and as a component of FAC scheme) should be administered to patients with disseminated breast cancer resistant to cytostatic drugs. This treatment is followed by remission and arrests the process for an average of 9 months (in some cases up to 30 months). Mean doses of 30-40 mg should be given to outpatients on days 1 and 8 of each course, with intervals between courses being 21-28 days. No apparent side-effects are observed. The total dose should be as high as 450-550 mg. Adjuvant antiestrogen treatment (tamoxifen) should be given to pre- and menopausal patients.
对于对细胞抑制药物耐药的播散性乳腺癌患者,应给予阿霉素(单独使用或作为FAC方案的组成部分)。这种治疗后会出现缓解,平均可使病情停滞9个月(某些情况下可达30个月)。每个疗程的第1天和第8天应给予门诊患者平均剂量为30 - 40毫克的药物,疗程间隔为21 - 28天。未观察到明显的副作用。总剂量应高达450 - 550毫克。绝经前和绝经患者应给予辅助抗雌激素治疗(他莫昔芬)。