Batra Jaskaran, Ankireddypalli Anvitha, Kanugula Ashok Kumar, Gorle Swathi, Kaur Jasleen
Department of Internal Medicine, UMPC McKeesport, McKeesport, USA.
Department of Endocrinology, University of Minnesota School of Medicine, Minneapolis, USA.
Cureus. 2023 Feb 27;15(2):e35548. doi: 10.7759/cureus.35548. eCollection 2023 Feb.
We present a case of a 29-year-old male who presented with thyrotoxic periodic paralysis (TPP) precipitated by acute alcohol intoxication. TPP is an endocrine emergency that presents with an episode of acute flaccid paralysis with hypokalemia in the setting of thyrotoxicosis. Individuals who present with TPP are thought to have an underlying genetic predisposition. Overactivation of the Na/K ATPase channel leads to large-scale intracellular shifts in potassium, leading to low serum levels and the clinical manifestations of TPP. Severe hypokalemia can lead to life-threatening complications such as ventricular arrhythmias and respiratory failure. Therefore, timely recognition and management are essential in cases of TPP. In addition, understanding the precipitating factors is necessary for adequate counseling of these patients to prevent further episodes.
我们报告一例29岁男性，因急性酒精中毒诱发甲状腺毒症性周期性瘫痪（TPP）。TPP是一种内分泌急症，表现为在甲状腺毒症背景下出现急性弛缓性麻痹发作并伴有低钾血症。出现TPP的个体被认为有潜在的遗传易感性。钠/钾ATP酶通道过度激活导致钾大量向细胞内转移，导致血清钾水平降低及TPP的临床表现。严重低钾血症可导致危及生命的并发症，如室性心律失常和呼吸衰竭。因此，对于TPP病例，及时识别和处理至关重要。此外，了解诱发因素对于对这些患者进行充分的咨询以防止再次发作是必要的。
