Alziadat Moayyad, Ismail Mourad
Department of Critical Care Medicine, St Joseph's University Medical Center, Paterson, New Jersey, USA.
Avicenna J Med. 2020 Oct 13;10(4):249-251. doi: 10.4103/ajm.ajm_54_20. eCollection 2020 Oct-Dec.
Thyrotoxic periodic paralysis (TPP) is a rare and serious manifestation of thyrotoxicosis that causes flaccid paralysis. In severe cases, it can be life-threatening due to respiratory failure and cardiac arrhythmias. TPP is due to increased sodium/potassium ATPase activity during thyrotoxic states, which is due to mutations encoding potassium channels. It is precipitated by situations that cause a surge in catecholamines, insulin, or both. It can be treated with potassium supplementation and nonselective beta blockers, and it can be prevented by establishing euthyroid state. With the increasing numbers of outpatient procedures performed nowadays and the stress related to these procedures, patients with TPP may develop paralysis after these procedures, so clinicians should be aware of this condition and the importance of identifying it in patients presenting with flaccid paralysis.
甲状腺毒症性周期性瘫痪（TPP）是甲状腺毒症的一种罕见且严重的表现形式，可导致弛缓性麻痹。在严重情况下，由于呼吸衰竭和心律失常，它可能危及生命。TPP是由于甲状腺毒症状态下钠/钾ATP酶活性增加所致，而这又归因于编码钾通道的基因突变。它由导致儿茶酚胺、胰岛素或两者激增的情况所诱发。可通过补充钾和使用非选择性β受体阻滞剂进行治疗，通过使甲状腺功能恢复正常状态来预防。随着如今门诊手术数量的增加以及与这些手术相关的压力，TPP患者在这些手术后可能会发生瘫痪，因此临床医生应了解这种情况以及在出现弛缓性麻痹的患者中识别它的重要性。
