Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, University of Balochistan, Quetta, Pakistan.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Pakistan.
Pak J Pharm Sci. 2022 Nov;35(6(Special)):1739-1746.
Grewia asiatica L. is a potential medicinal plant used for various diseases in traditional medicine. Current study was aimed to evaluate the cardio protective, anti-inflammatory, analgesic and CNS depressant activities of Grewia asiatica L. fruit extract. In cardio protective activity myocardial injury was produced by injection of Isoproterenol (200 mg/kg, s.c), G. asiatica 250 and 500mg/kg treated groups significantly (p<0.05) decreased the level of serum AST, ALT, LDH and CKMB, hence produced cardio protective effect. In analgesic activities G. asiatica produced significant (p<0.05) analgesic effects in acetic acid induced writhing, formalin, paw pressure and tail immersion test. G. asiatica at 250 and 500mg/kg oral dose, significantly (p<0.05) reduced the rat paw edema in carrageen an induced rat paw edema test. G. asiatica extract also produced significant CNS depressant effects in open field, hole board and thiopental sodium induced sleeping time. Findings of the current study suggest that G. asiatica fruit extract showed potential pharmacological effects and can be utilized in alternative medicine.
三叶海棠果是一种有潜力的药用植物，在传统医学中用于治疗各种疾病。本研究旨在评估三叶海棠果提取物的心脏保护、抗炎、镇痛和中枢神经抑制活性。在心脏保护活性中，通过注射异丙肾上腺素（200mg/kg，皮下注射）产生心肌损伤，250 和 500mg/kg 的三叶海棠果治疗组显著（p<0.05）降低了血清 AST、ALT、LDH 和 CKMB 的水平，因此产生了心脏保护作用。在镇痛活性中，三叶海棠果在醋酸诱导的扭体、福尔马林、足压和尾浸试验中产生了显著的（p<0.05）镇痛作用。250 和 500mg/kg 的口服剂量的三叶海棠果显著（p<0.05）降低了角叉菜胶诱导的大鼠足肿胀试验中的大鼠足肿胀。三叶海棠果提取物还在旷场、洞板和戊巴比妥钠诱导的睡眠时间中产生了显著的中枢神经抑制作用。本研究的结果表明，三叶海棠果果实提取物具有潜在的药理作用，可以在替代医学中应用。
