Akhtar Bushra, Ashraf Muhammad, Javeed Aqeel, Sharif Ali, Akhtar Muhammad Furqan, Saleem Ammara, Hamid Irfan, Alvi Sadia, Murtaza Ghulam
Acta Pol Pharm. 2016 Jul;73(4):983-989.
The present study was aimed to assess biological (analgesic, antipyretic and anti-inflammatory) activities of methanolic and aqueous fruit extracts of Grewia asiatica. The study was performed on albino mice. Analgesic effect of the extracts was determined by acetic acid induced writhing. Antipyretic potential of the tested fruit extracts was assessed by brewer's yeast induced pyrexia. Carrageenan induced paw edema method was used to evaluate the anti-inflammatory activity. Both the extracts showed biological effects in a dose dependent fashion at doses 125 mg/kg, 250 mg/kg and 500 mg/kg orally. Analysis of variance (ANOVA) was used for data analysis and the values having p-value smaller than 0.05 were considered significant. Both the extracts had significant analgesic, antipyretic and anti-inflammatory activities.
本研究旨在评估亚洲格木果实甲醇提取物和水提取物的生物学（镇痛、解热和抗炎）活性。该研究在白化小鼠身上进行。通过乙酸诱导扭体试验测定提取物的镇痛作用。通过啤酒酵母诱导发热来评估受试果实提取物的解热潜力。采用角叉菜胶诱导足跖肿胀法评估抗炎活性。两种提取物在口服剂量为125mg/kg、250mg/kg和500mg/kg时均呈剂量依赖性显示出生物学效应。采用方差分析（ANOVA）进行数据分析，p值小于0.05的值被认为具有显著性。两种提取物均具有显著的镇痛、解热和抗炎活性。
