Department of Mathematics, National Institute of Technology Uttarakhand, Srinagar, India.
Department of Mechanical Engineering, Manipal University, Manipal, India.
J Biol Dyn. 2023 Dec;17(1):2182373. doi: 10.1080/17513758.2023.2182373.
In this paper, we developed a mathematical model to simulate virus transport through a viscous background flow driven by the natural pumping mechanism. Two types of respiratory pathogens viruses (SARS-Cov-2 and Influenza-A) are considered in this model. The Eulerian-Lagrangian approach is adopted to examine the virus spread in axial and transverse directions. The Basset-Boussinesq-Oseen equation is considered to study the effects of gravity, virtual mass, Basset force, and drag forces on the viruses transport velocity. The results indicate that forces acting on the spherical and non-spherical particles during the motion play a significant role in the transmission process of the viruses. It is observed that high viscosity is responsible for slowing the virus transport dynamics. Small sizes of viruses are found to be highly dangerous and propagate rapidly through the blood vessels. Furthermore, the present mathematical model can help to better understand the viruses spread dynamics in a blood flow.
本文开发了一个数学模型,通过自然泵送机制驱动的粘性背景流来模拟病毒的传输。该模型考虑了两种类型的呼吸道病原体病毒(SARS-CoV-2 和流感病毒 A)。采用欧拉-拉格朗日方法研究病毒在轴向和横向的传播。考虑了 Basset-Boussinesq-Oseen 方程来研究重力、虚拟质量、Basset 力和阻力对病毒传输速度的影响。结果表明,在运动过程中作用于球形和非球形颗粒的力对病毒的传播过程起着重要作用。观察到高粘度会减缓病毒的传输动力学。发现小尺寸的病毒非常危险,并且可以通过血管迅速传播。此外,本数学模型有助于更好地理解血流中病毒的传播动力学。