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甲型H1N1流感病毒通过食管内唾液流动的传播:一个数学模型

Propagation of H1N1 virus through saliva movement in oesophagus: a mathematical model.

作者信息

Ram Daya, Bhandari D S, Tripathi Dharmendra, Sharma Kushal

机构信息

Department of Mathematics, Malaviya National Institute of Technology Jaipur, Rajasthan, 302017 India.

Department of Mathematics, National Institute of Technology, Uttarakhand, Srinagar, 246174 India.

出版信息

Eur Phys J Plus. 2022;137(7):866. doi: 10.1140/epjp/s13360-022-03070-2. Epub 2022 Jul 27.

Abstract

H1N1 (Swine flu) is caused by the influenza A virus which belongs to the Orthomyxoviridae family. Influenza A is very harmful to the elderly, and people with chronic respiratory disease and cardiovascular disease. Therefore, it is essential to analyse the behaviour of virus transmission through the saliva movement in oesophagus. A mathematical paradigm is developed to study the saliva movement under the applications of transverse magnetic field. Jeffrey fluid model is considered for saliva to show the viscoelastic nature. The flow nature is considered creeping and assumptions of long wavelength and low Reynolds number are adopted for analytical solutions. The Basset-Boussinesq-Oseen equation is employed to understand the propagation of H1N1 virus through saliva under the effect of applicable forces such as gravity, virtual mass, basset force, and drag forces. The suitable data for saliva, oesophagus and H1N1 virus are taken from the existing literature for simulation of the results using MATLAB software. From the graphical results, it is observed that the susceptibility to viral infections is less because the magnetic field reduces the motion of the virus particle. Further, the chances of infections in males are more as compared to females and children due to variation in viscosity of saliva. Such findings provide an understanding of the mechanics of the virus floating through the saliva (viscoelastic fluids) in the oesophagus.

摘要

H1N1(猪流感)由属于正粘病毒科的甲型流感病毒引起。甲型流感对老年人以及患有慢性呼吸道疾病和心血管疾病的人危害极大。因此,分析病毒通过食管中唾液流动进行传播的行为至关重要。建立了一个数学模型来研究横向磁场作用下的唾液流动。考虑用杰弗里流体模型来描述唾液,以体现其粘弹性本质。流动性质被视为蠕动流,并采用长波长和低雷诺数的假设来获得解析解。运用巴塞特 - 布辛涅斯克 - 奥森方程来理解在重力、虚拟质量力、巴塞特力和阻力等适用力的作用下,H1N1病毒通过唾液的传播情况。唾液、食管和H1N1病毒的合适数据取自现有文献,使用MATLAB软件对结果进行模拟。从图形结果可以看出,由于磁场降低了病毒颗粒的运动,所以病毒感染的易感性较低。此外,由于唾液粘度的差异,男性相比女性和儿童感染的几率更高。这些发现有助于理解病毒在食管中通过唾液(粘弹性流体)漂浮的力学原理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e113/9326416/ffd97ec3e228/13360_2022_3070_Fig1_HTML.jpg

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