在巴西队列中 COVID-19 大流行期间未检测到 RSV 和流感：社区中传播率较低的可能作用。

Absence of detection of RSV and influenza during the COVID-19 pandemic in a Brazilian cohort: Likely role of lower transmission in the community.

机构信息

Social Responsibility - PROADI-SUS, Hospital Moinhos de Vento, Porto Alegre, Brazil.

School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.

出版信息

J Glob Health. 2021 Mar 1;11:05007. doi: 10.7189/jogh.11.05007.

DOI:10.7189/jogh.11.05007

PMID:33791096

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7979153/

Abstract

BACKGROUND

Respiratory syncytial virus (RSV) and influenza are prevalent seasonal community viruses. Although not completely understood, SARS-CoV-2 may have the same means of transmission. Preventive social measures aimed at preventing SARS-CoV-2 spread could impact transmission of other respiratory viruses as well. The aim of this study is to report the detection of RSV and influenza during the period of social distancing due to COVID-19 pandemic in a heavily affected community.

METHODS

Prospective study with pediatric and adult populations seeking care for COVID-19-like symptoms during the fall and winter of 2020 at two hospitals in Southern Brazil. RT-PCR tests for SARS-CoV-2, influenza A (Flu A), influenza B (Flu B) and respiratory syncytial virus (RSV) was performed for all participants.

RESULTS

1435 suspected COVID-19 participants (1137 adults, and 298 children). were included between May and August. Median age was 37.7 years (IQR = 29.6-47.7), and 4.92 years (IQR = 1.96-9.53), for the adult and child cohorts, respectively. SARS-CoV-2 was positive in 469 (32.7%) while influenza and RSV were not detected at all.

CONCLUSIONS

Measures to reduce SARS-CoV-2 transmission likely exerted a huge impact in the spread of alternate respiratory pathogens. These findings contribute to the knowledge about the dynamics of virus spread. Further, it may be considered for guiding therapeutic choices for these other viruses.

摘要

背景

呼吸道合胞病毒（RSV）和流感是常见的季节性社区病毒。尽管尚未完全了解，但 SARS-CoV-2 可能具有相同的传播方式。旨在预防 SARS-CoV-2 传播的预防社交措施也可能影响其他呼吸道病毒的传播。本研究旨在报告在 COVID-19 大流行期间因社交距离而导致的一个受严重影响社区中 RSV 和流感的检测情况。

方法

这是一项前瞻性研究，纳入了 2020 年秋季和冬季在巴西南部的两家医院因 COVID-19 样症状就诊的儿科和成人人群。对所有参与者均进行了 SARS-CoV-2、甲型流感（Flu A）、乙型流感（Flu B）和呼吸道合胞病毒（RSV）的 RT-PCR 检测。

结果

共纳入了 1435 例疑似 COVID-19 患者（成人 1137 例，儿童 298 例），纳入时间为 5 月至 8 月。成人组和儿童组的中位年龄分别为 37.7 岁（IQR=29.6-47.7）和 4.92 岁（IQR=1.96-9.53）。SARS-CoV-2 阳性者有 469 例（32.7%），而流感和 RSV 均未检出。