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The potential role of opioid vaccines and monoclonal antibodies in the opioid overdose crisis.

作者信息

Martinez Suky, Harris Hannah, Chao Thomas, Luba Rachel, Pravetoni Marco, Comer Sandra D, Jones Jermaine D

机构信息

Division on Substance Use Disorders, Columbia University Irving Medical Center & New York State Psychiatric Institute, New York, NY, USA.

Behavioural Reward Affect + Impulsivity Neuroscience Lab, Faculty of Medicine, the University of British Columbia, Vancouver, Bc, Canada.

出版信息

Expert Opin Investig Drugs. 2023 Mar;32(3):181-185. doi: 10.1080/13543784.2023.2187286. Epub 2023 Mar 6.

DOI:10.1080/13543784.2023.2187286
PMID:36863002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10065938/
Abstract
摘要

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本文引用的文献

1
Improving Translational Research Outcomes for Opioid Use Disorder Treatments.改善阿片类物质使用障碍治疗的转化研究成果。
Curr Addict Rep. 2021 Mar;8(1):109-121. doi: 10.1007/s40429-020-00353-5. Epub 2021 Jan 12.
2
Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding.与阿片类药物和尼古丁结合的药物特异性单克隆抗体的结构揭示了一种共同的结合模式。
Structure. 2023 Jan 5;31(1):20-32.e5. doi: 10.1016/j.str.2022.11.008. Epub 2022 Dec 12.
3
Advancing humanized monoclonal antibody for counteracting fentanyl toxicity towards clinical development.推进人源化单克隆抗体以对抗芬太尼毒性，迈向临床开发。
Hum Vaccin Immunother. 2022 Nov 30;18(6):2122507. doi: 10.1080/21645515.2022.2122507. Epub 2022 Oct 4.
4
Unique Pharmacology, Brain Dysfunction, and Therapeutic Advancements for Fentanyl Misuse and Abuse.芬太尼滥用和成瘾的独特药理学、大脑功能障碍和治疗进展。
Neurosci Bull. 2022 Nov;38(11):1365-1382. doi: 10.1007/s12264-022-00872-3. Epub 2022 May 15.
5
Pharmacological Profiling of Antifentanyl Monoclonal Antibodies in Combination with Naloxone in Pre- and Postexposure Models of Fentanyl Toxicity.在芬太尼中毒的暴露前和暴露后模型中，联合纳洛酮对抗芬太尼单克隆抗体进行药物特征分析。
J Pharmacol Exp Ther. 2022 May;381(2):129-136. doi: 10.1124/jpet.121.001048. Epub 2022 Feb 13.
6
Current status of vaccines for substance use disorders: A brief review of human studies.物质使用障碍疫苗的现状：人类研究的简要综述。
J Neurol Sci. 2022 Mar 15;434:120098. doi: 10.1016/j.jns.2021.120098. Epub 2021 Dec 16.
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J Addict Med. 2020 Jul/Aug;14(4):331-336. doi: 10.1097/ADM.0000000000000592.