Survey of explainable artificial intelligence techniques for biomedical imaging with deep neural networks.

Artificial Intelligence (AI) techniques of deep learning have revolutionized the disease diagnosis with their outstanding image classification performance. In spite of the outstanding results, the widespread adoption of these techniques in clinical practice is still taking place at a moderate pace. One of the major hindrance is that a trained Deep Neural Networks (DNN) model provides a prediction, but questions about why and how that prediction was made remain unanswered. This linkage is of utmost importance for the regulated healthcare domain to increase the trust in the automated diagnosis system by the practitioners, patients and other stakeholders. The application of deep learning for medical imaging has to be interpreted with caution due to the health and safety concerns similar to blame attribution in the case of an accident involving autonomous cars. The consequences of both a false positive and false negative cases are far reaching for patients' welfare and cannot be ignored. This is exacerbated by the fact that the state-of-the-art deep learning algorithms comprise of complex interconnected structures, millions of parameters, and a 'black box' nature, offering little understanding of their inner working unlike the traditional machine learning algorithms. Explainable AI (XAI) techniques help to understand model predictions which help develop trust in the system, accelerate the disease diagnosis, and meet adherence to regulatory requirements. This survey provides a comprehensive review of the promising field of XAI for biomedical imaging diagnostics. We also provide a categorization of the XAI techniques, discuss the open challenges, and provide future directions for XAI which would be of interest to clinicians, regulators and model developers.