Zhang Zhiheng, Hu Yao, Ji Hangyan, Lin Qianzhu, Li Xiaojing, Sang Shangyuan, Julian McClements David, Chen Long, Long Jie, Jiao Aiquan, Xu Xueming, Jin Zhengyu, Qiu Chao
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu 214122, China.
College of Light Industry and Food Engineering, Nanjing Forestry University, Jiangsu 210037, China.
Food Chem. 2023 Jul 30;415:135736. doi: 10.1016/j.foodchem.2023.135736. Epub 2023 Feb 18.
Core-shell biopolymer nanoparticles are assembled from a hydrophobic protein (zein) core and a hydrophilic polysaccharide (carboxymethyl dextrin) shell. The nanoparticles were shown to have good stability and the ability to protect quercetin from chemical degradation under long-term storage, pasteurization, and UV irradiation. Spectroscopy analysis shows that electrostatic, hydrogen bonding, and hydrophobic interactions are the main driving forces for the formation of composite nanoparticles. Quercetin coated with nanoparticles significantly enhanced its antioxidant and antibacterial activities and showed good stability and slow release in vitro during simulated gastrointestinal digestion. Furthermore, the encapsulation efficiency of carboxymethyl dextrin-coated zein nanoparticles (81.2%) for quercetin was significantly improved compared with that of zein nanoparticles alone (58.4%). These results indicate that carboxymethyl dextrin-coated zein nanoparticles can significantly improve the bioavailability of hydrophobic nutrient molecules such as quercetin and provide a valuable reference for their application in the field of biological delivery of energy drinks and food.
核壳生物聚合物纳米颗粒由疏水性蛋白质（玉米醇溶蛋白）核和亲水性多糖（羧甲基糊精）壳组装而成。研究表明，这些纳米颗粒具有良好的稳定性，并且能够在长期储存、巴氏杀菌和紫外线照射下保护槲皮素免受化学降解。光谱分析表明，静电、氢键和疏水相互作用是形成复合纳米颗粒的主要驱动力。包覆有纳米颗粒的槲皮素显著增强了其抗氧化和抗菌活性，并且在模拟胃肠道消化过程中在体外表现出良好的稳定性和缓释性能。此外，羧甲基糊精包覆的玉米醇溶蛋白纳米颗粒对槲皮素的包封率（81.2%）相比单独的玉米醇溶蛋白纳米颗粒（58.4%）有显著提高。这些结果表明，羧甲基糊精包覆的玉米醇溶蛋白纳米颗粒能够显著提高槲皮素等疏水性营养分子的生物利用度，并为其在能量饮料和食品生物递送领域的应用提供有价值的参考。
