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PPM1B:从生物学功能到疾病的全面概述。

A comprehensive overview of PPM1B: From biological functions to diseases.

机构信息

School of Pharmacy and Pharmaceutical Sciences, Institute of Materia Medica, Shandong First Medical University, Shandong Academy of Medical Sciences, NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Key Lab for Rare & Uncommon Diseases of Shandong Province, Ji'nan, 250117, Shandong, China.

Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Ji'nan, 250012, Shandong, China.

出版信息

Eur J Pharmacol. 2023 May 15;947:175633. doi: 10.1016/j.ejphar.2023.175633. Epub 2023 Mar 1.

Abstract

Reversible phosphorylation of proteins is an important mechanism that regulates cellular processes, which are precisely regulated by protein kinases and phosphatases. PPM1B is a metal ion-dependent serine/threonine protein phosphatase, which regulates multiple biological functions by targeting substrate dephosphorylation, such as cell cycle, energy metabolism, inflammatory responses. In this review, we summarized the occurrent understandings of PPM1B focused on its regulation of signaling pathways, related diseases, and small-molecular inhibitors, which may provide new insights for the identification of PPM1B inhibitors and the treatment of PPM1B-related diseases.

摘要

蛋白质的可逆磷酸化是调节细胞过程的重要机制,而这一过程受到蛋白激酶和磷酸酶的精确调控。PPM1B 是一种依赖于金属离子的丝氨酸/苏氨酸蛋白磷酸酶,通过靶向底物去磷酸化来调节多种生物功能,如细胞周期、能量代谢、炎症反应。在这篇综述中,我们总结了目前对 PPM1B 的认识,重点介绍了其对信号通路的调节、相关疾病以及小分子抑制剂的作用,这可能为鉴定 PPM1B 抑制剂和治疗 PPM1B 相关疾病提供新的思路。

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