乌干达西南部一家教学医院诊断的威尔姆斯瘤病例的一年总体生存率及其预测因素：一项回顾性队列研究。
One year overall survival of wilms tumor cases and its predictors, among children diagnosed at a teaching hospital in South Western Uganda: a retrospective cohort study.
机构信息
Department of Surgery, Mbarara University of Science and Technology, Faculty of Medicine, Mbarara, Uganda.
Department of Anatomy, Faculty of Medicine Soroti University, Soroti, Uganda.
出版信息
BMC Cancer. 2023 Mar 2;23(1):196. doi: 10.1186/s12885-023-10601-2.
BACKGROUND
Wilms tumor (WT) is the second most common solid tumor in Africa with both low overall survival (OS) and event-free survival (EFS) rates. However, no known factors are predicting this poor overall survival.
OBJECTIVE
The study was to determine the one-year overall survival of WT cases and its predictors among children diagnosed in the pediatric oncology and surgical units of Mbarara regional referral hospital (MRRH), western Uganda.
METHODOLOGY
Children's treatment charts and files diagnosed and managed for WT were retrospectively followed up for the period between January 2017 to January 2021. Charts of children with histologically confirmed diagnoses were reviewed for demographics, clinical and histological characteristics, as well as treatment modalities.
RESULTS
One-year overall survival was found to be 59.3% (95% CI: 40.7-73.3), with tumor size greater than 15 cm (p 0.021) and unfavorable WT type (p 0.012) being the predominant predictors.
CONCLUSION
Overall survival (OS) of WT at MRRH was found to be 59.3%, and predictive factors noted were unfavorable histology and tumor size greater than 115 cm.
背景
威尔姆斯瘤（WT）是非洲第二大常见实体瘤，其总生存率（OS）和无事件生存率（EFS）均较低。然而，目前尚不清楚哪些因素可以预测这种较差的总体生存率。
目的
本研究旨在确定乌干达西部姆巴拉拉地区转诊医院（MRRH）儿科肿瘤学和外科病房诊断的 WT 病例的一年总体生存率及其预测因素。
方法
回顾性随访了 2017 年 1 月至 2021 年 1 月期间在 MRRH 接受治疗和管理的 WT 患儿的治疗图表和档案。对组织学确诊的患儿的图表进行了评估，以了解其人口统计学、临床和组织学特征以及治疗方式。
结果
发现一年总体生存率为 59.3%（95%CI：40.7-73.3），肿瘤大小大于 15cm（p<0.021）和不良 WT 类型（p<0.012）是主要的预测因素。
结论
MRRH 的 WT 总体生存率为 59.3%，不良组织学和肿瘤大小大于 115cm 是 noted 到的预测因素。
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