Department of Rheumatology, Affiliated Hospital of Inner Mongolia Medical University, Huhehaote 010059, China.
Department of Nephrology and Rheumatology, Hohhot First Hospital, Huhehaote 010000, China.
J Environ Public Health. 2023 Feb 21;2023:2843979. doi: 10.1155/2023/2843979. eCollection 2023.
. At present, glucocorticoids combined with cyclophosphamide are still used for the clinical treatment of systemic lupus erythematosus (SLE). However, long-term practice has shown that drug treatment currently has the phenomena of long treatment duration, uncontrollable conditions in a short period of time, and unsatisfactory efficacy. DNA immunoadsorption therapy is a newly developed therapy. The combination of drugs and DNA immunoadsorption has been reported for the treatment of SLEN in clinics for a long time. In this study, we observed the effects of DNA immunoadsorption combined with drug therapy on immune function and renal function in patients with systemic lupus erythematosus (SLE). The results showed that the DNA immunosorbent assay combined with medication in the treatment of SLE could quickly and specifically remove pathogenic substances from patients, improve renal function, immune function, and complement levels in patients, and help to relieve disease activity.
目前,临床治疗系统性红斑狼疮(SLE)仍采用糖皮质激素联合环磷酰胺,但长期实践表明,药物治疗目前存在治疗周期长、短期内病情难以控制、疗效不佳等现象。DNA 免疫吸附疗法是一种新发展起来的治疗方法,药物联合 DNA 免疫吸附疗法在临床上用于治疗 SLEN 已有很长一段时间。本研究观察 DNA 免疫吸附联合药物治疗对系统性红斑狼疮(SLE)患者免疫功能和肾功能的影响,结果表明,DNA 免疫吸附剂联合药物治疗 SLE 可快速、特异地从患者体内清除致病物质,改善患者肾功能、免疫功能及补体水平,有助于缓解病情活动。