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通过无果基因和肝细胞核因子4整合脂质代谢、信息素产生及感知

Integrating lipid metabolism, pheromone production and perception by Fruitless and Hepatocyte nuclear factor 4.

作者信息

Sun Jie, Liu Wen-Kan, Ellsworth Calder, Sun Qian, Pan Yu-Feng, Huang Yi-Chun, Deng Wu-Min

机构信息

Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA 70112, USA.

出版信息

bioRxiv. 2023 Feb 23:2023.02.23.529767. doi: 10.1101/2023.02.23.529767.

DOI:10.1101/2023.02.23.529767
PMID:36865119
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9980076/
Abstract

UNLABELLED

Sexual attraction and perception, governed by separate genetic circuits in different organs, are crucial for mating and reproductive success, yet the mechanisms of how these two aspects are integrated remain unclear. In , the male-specific isoform of Fruitless (Fru), Fru , is known as a master neuro-regulator of innate courtship behavior to control perception of sex pheromones in sensory neurons. Here we show that the non-sex specific Fru isoform (Fru ) is necessary for pheromone biosynthesis in hepatocyte-like oenocytes for sexual attraction. Loss of Fru in oenocytes resulted in adults with reduced levels of the cuticular hydrocarbons (CHCs), including sex pheromones, and show altered sexual attraction and reduced cuticular hydrophobicity. We further identify ( ) as a key target of Fru in directing fatty acid conversion to hydrocarbons in adult oenocytes. - and -depletion disrupts lipid homeostasis, resulting in a novel sex-dimorphic CHC profile, which differs from - and -dependent sexual dimorphism of the CHC profile. Thus, Fru couples pheromone perception and production in separate organs for precise coordination of chemosensory communication that ensures efficient mating behavior.

TEASER

Fruitless and lipid metabolism regulator HNF4 integrate pheromone biosynthesis and perception to ensure robust courtship behavior.

摘要

未标注

性吸引力和性感知由不同器官中的独立基因回路控制，对交配和繁殖成功至关重要，但这两个方面如何整合的机制仍不清楚。在果蝇中，无果基因（Fru）的雄性特异性异构体FruM，是先天性求偶行为的主要神经调节因子，可控制感觉神经元对性信息素的感知。在此，我们表明非性别特异性的Fru异构体（FruA）对于类肝细胞样卵母细胞中用于性吸引的信息素生物合成是必需的。卵母细胞中FruA的缺失导致成虫表皮碳氢化合物（CHC）水平降低，包括性信息素，并表现出性吸引力改变和表皮疏水性降低。我们进一步确定Hnf4（HNF4）是FruA在指导成年卵母细胞中脂肪酸转化为碳氢化合物的关键靶点。Hnf4和Hnf4的缺失会破坏脂质稳态，导致一种新的性别二态性CHC谱，这与Sox10和Fer1依赖的CHC谱的性别二态性不同。因此，Fru在不同器官中协调信息素的感知和产生，以精确协调化学感应通讯，确保有效的交配行为。

预告

无果基因和脂质代谢调节因子HNF4整合信息素生物合成和感知，以确保稳健的求偶行为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388a/9980076/cbfc7ec86ced/nihpp-2023.02.23.529767v1-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388a/9980076/134528dd88d0/nihpp-2023.02.23.529767v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388a/9980076/efe5c6cc5747/nihpp-2023.02.23.529767v1-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388a/9980076/e403496b1de0/nihpp-2023.02.23.529767v1-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388a/9980076/614bd51b7daf/nihpp-2023.02.23.529767v1-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388a/9980076/2878340c2883/nihpp-2023.02.23.529767v1-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388a/9980076/b0f49a999cf9/nihpp-2023.02.23.529767v1-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388a/9980076/92dcd8778588/nihpp-2023.02.23.529767v1-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388a/9980076/cbfc7ec86ced/nihpp-2023.02.23.529767v1-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388a/9980076/134528dd88d0/nihpp-2023.02.23.529767v1-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388a/9980076/efe5c6cc5747/nihpp-2023.02.23.529767v1-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388a/9980076/e403496b1de0/nihpp-2023.02.23.529767v1-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388a/9980076/614bd51b7daf/nihpp-2023.02.23.529767v1-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388a/9980076/2878340c2883/nihpp-2023.02.23.529767v1-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388a/9980076/b0f49a999cf9/nihpp-2023.02.23.529767v1-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388a/9980076/92dcd8778588/nihpp-2023.02.23.529767v1-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/388a/9980076/cbfc7ec86ced/nihpp-2023.02.23.529767v1-f0008.jpg

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