Wang Qian, Jiang Yue, Lin Li, Li Sheng, Lv Jiagao, Chen Jun
Department of Internal Medicine, Division of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Surg. 2023 Feb 14;10:1097287. doi: 10.3389/fsurg.2023.1097287. eCollection 2023.
Primary atrial tumors are relatively rare and predominantly benign. However, some atrial tumors may be malignant and are associated with poor outcome. Currently, it is hard to determine the malignance of atrial tumors by preoperative clinical presentation or by echocardiography. We aimed to report the difference in the clinical characteristics of patients with benign and malignant atrial tumor.
This was a single-center retrospective study. A total of 194 patients with primary atrial tumor admitted to our center between 2012 and 2021 were included. The clinical characteristics of patients with benign and malignant tumor were compared.
Benign and malignant tumor accounted for 93% ( = 180) and 7% ( = 14) of the total patients, respectively. Malignant atrial tumor tended to occur in younger patients ( < 0.05), was more likely to be located at the right atrium ( < 0.05), and tended to attach to the atrial wall or valve instead of the atrial septum. Fever symptoms were more common in patients with malignant tumors than in patients with benign tumors ( < 0.05). Compared to benign tumor, patients with malignant atrial tumor also demonstrated higher rates of fever, lower rates of increasing fibrinogen, increased blood glucose ( < 0.05), significantly longer prothrombin time, and lower prothrombin activity ( < 0.05). Patients with malignant primary atrial tumor had higher mortality rate, tumor metastasis rate, and tumor recurrence rate than patients with benign primary atrial tumor ( < 0.05).
We compared the clinical characteristics of patients with benign and malignant atrial tumor. These findings provide valuable information to preoperatively determine the malignance of atrial tumor and thus guide surgical treatment.
原发性心房肿瘤相对罕见，且大多为良性。然而，一些心房肿瘤可能是恶性的，预后较差。目前，很难通过术前临床表现或超声心动图来确定心房肿瘤的恶性程度。我们旨在报告良性和恶性心房肿瘤患者的临床特征差异。
这是一项单中心回顾性研究。纳入了2012年至2021年间在我们中心住院的194例原发性心房肿瘤患者。比较了良性和恶性肿瘤患者的临床特征。
良性和恶性肿瘤分别占总患者数的93%（n = 180）和7%（n = 14）。恶性心房肿瘤倾向于发生在年轻患者中（P < 0.05），更有可能位于右心房（P < 0.05），并且倾向于附着于心房壁或瓣膜而非房间隔。发热症状在恶性肿瘤患者中比良性肿瘤患者更常见（P < 0.05）。与良性肿瘤相比，恶性心房肿瘤患者还表现出更高的发热率、更低的纤维蛋白原升高率、血糖升高（P < 0.05）、凝血酶原时间显著延长以及凝血酶原活性降低（P < 0.05）。原发性恶性心房肿瘤患者的死亡率、肿瘤转移率和肿瘤复发率均高于原发性良性心房肿瘤患者（P < 0.05）。
我们比较了良性和恶性心房肿瘤患者的临床特征。这些发现为术前确定心房肿瘤的恶性程度并指导手术治疗提供了有价值的信息。
