肠贾第虫克隆对抗贾第虫药物反应的异质性。

Heterogeneity in the responses of clones of Giardia intestinalis to anti-giardial drugs.

作者信息

Boreham P F, Phillips R E, Shepherd R W

机构信息

Queensland Institute of Medical Research, Bramston Terrace, Brisbane, Australia.

出版信息

Trans R Soc Trop Med Hyg. 1987;81(3):406-7. doi: 10.1016/0035-9203(87)90151-9.

DOI:10.1016/0035-9203(87)90151-9

PMID:3686635

Abstract

Clones of two stocks of Giardia intestinalis have been tested by the [3H]thymidine uptake assay to determine their sensitivity to metronidazole, tinidazole, furazolidone and quinacrine. Each stock was not homogeneous with respect to drug sensitivity but was composed of different populations of organisms. Doubling times of lines derived from clones of a stock did not vary significantly. These findings may, in part, account for treatment failures in human giardiasis patients.

摘要

已通过[3H]胸苷摄取试验对两株肠贾第鞭毛虫进行克隆，以确定它们对甲硝唑、替硝唑、呋喃唑酮和奎纳克林的敏感性。每株在药物敏感性方面并非同质，而是由不同的生物群体组成。来自一株克隆的细胞系的倍增时间没有显著差异。这些发现可能部分解释了人类贾第鞭毛虫病患者治疗失败的原因。