Department of Surgery, University of Mississippi Medical Center, Jackson, MS, USA.
Department of Surgery, Division of Surgical Oncology, University of Mississippi Medical Center, Jackson, MS, USA.
Am Surg. 2023 Aug;89(8):3526-3527. doi: 10.1177/00031348231161080. Epub 2023 Mar 3.
Neuroendocrine tumors are defined as tumors that express neuroendocrine markers, specifically synaptophysin and/or chromogranin in at least 50% of tumor cells. To date, neuroendocrine cancers of the breast are extremely rare with reports that they account for less than 1% of all neuroendocrine tumors and less than .1% of all breast cancers. Limited literature exists to guide treatment decisions tailored to neuroendocrine tumors of the breast, despite the possibility that they may be associated with an overall worse prognosis. We present a rare case of neuroendocrine ductal carcinoma in situ (NE-DCIS) which was discovered upon workup for bloody nipple discharge. In this case, NE-DCIS was managed with the standard recommended treatment regimen for ductal carcinoma in situ.
神经内分泌肿瘤被定义为表达神经内分泌标志物的肿瘤，在至少 50%的肿瘤细胞中特异性表达突触素和/或嗜铬粒蛋白。迄今为止，乳腺神经内分泌癌极为罕见，据报道，其占所有神经内分泌肿瘤的比例不到 1%，占所有乳腺癌的比例不到 0.1%。尽管神经内分泌肿瘤可能与整体预后较差有关，但针对乳腺神经内分泌肿瘤的治疗决策指导，相关的文献却很有限。我们报告了一例罕见的乳腺神经内分泌导管原位癌（NE-DCIS），该病例是在因血性乳头溢液进行检查时发现的。在这种情况下，NE-DCIS 采用了导管原位癌标准推荐的治疗方案进行治疗。
