Ferrarelli Fabio
Int Clin Psychopharmacol. 2023 May 1;38(3):187-188. doi: 10.1097/YIC.0000000000000467. Epub 2023 Mar 6.
Sleep disturbance is commonly reported in patients with schizophrenia spectrum disorder (SSD) in the clinical setting. Sleep features can be assessed subjectively, with self-report sleep questionnaires, and objectively with actigraphy and electroencephalogram recordings. Traditionally, electroencephalogram studies have focused on sleep architecture. More recently, numerous studies have investigated alterations in sleep-specific rhythms, including electroencephalogram oscillations, such as sleep spindles and slow waves, in patients with SSD compared with control subjects. Here, I briefly discuss how sleep disturbance is highly prevalent in patients with SSD and I present findings from studies demonstrating abnormalities in sleep architecture and sleep-oscillatory rhythms, with an emphasis on sleep spindles and slow-wave deficits, in these patients. This increasing body of evidence highlights the importance of sleep disturbance in SSD and points to several future research directions with related clinical implications, thus showing that sleep disturbance is more than just a symptom in these patients.
在临床环境中，睡眠障碍在精神分裂症谱系障碍（SSD）患者中普遍存在。睡眠特征可以通过自我报告睡眠问卷进行主观评估，也可以通过活动记录仪和脑电图记录进行客观评估。传统上，脑电图研究主要关注睡眠结构。最近，大量研究调查了SSD患者与对照受试者相比，特定睡眠节律的改变，包括脑电图振荡，如睡眠纺锤波和慢波。在此，我简要讨论睡眠障碍在SSD患者中如何高度普遍，并展示研究结果，这些研究表明这些患者存在睡眠结构和睡眠振荡节律异常，重点是睡眠纺锤波和慢波缺陷。越来越多的证据凸显了睡眠障碍在SSD中的重要性，并指出了几个具有相关临床意义的未来研究方向，从而表明睡眠障碍在这些患者中不仅仅是一种症状。
