Brenig Alicia, Broekaert Ilse, Gerner Patrick, Posovszky Carsten, Hünseler Christoph, Joachim Alexander
Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Department of Pediatrics and Adolescent Medicine, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Int J Colorectal Dis. 2023 Mar 3;38(1):59. doi: 10.1007/s00384-023-04351-7.
To assess the current attitude and the status quo towards the use of microbiome analysis and fecal microbiota transfer (FMT) in pediatric patients in German-speaking pediatric gastroenterology centers.
A structured online survey among all certified facilities of the German-speaking society of pediatric gastroenterology and nutrition (GPGE) was conducted from November 01, 2020, until March 30, 2021.
A total of 71 centers were included in the analysis. Twenty-two centers (31.0%) use diagnostic microbiome analysis, but only a few perform analysis frequently (2; 2.8%) or regularly (1; 1.4%). Eleven centers (15.5%) have performed FMT as a therapeutic approach. Most of these centers use individual in-house donor screening programs (61.5%). One-third (33.8%) of centers rate the therapeutic impact of FMT as high or moderate. More than two-thirds (69.0%) of all participants are willing to participate in studies assessing the therapeutic effect of FMT.
Guidelines for microbiome analyses and FMT in pediatric patients and clinical studies investigating their benefits are absolutely necessary to improve the patient-centered care in pediatric gastroenterology. The long-term and successful establishment of pediatric FMT centers with standardized procedures for patient selection, donor screening, application route, volume, and frequency of use is highly required to obtain a safe therapy.
评估德语区儿科胃肠病学中心对儿科患者使用微生物组分析和粪便微生物群移植（FMT）的当前态度和现状。
于2020年11月1日至2021年3月30日对德语区儿科胃肠病学和营养学会（GPGE）的所有认证机构进行了一项结构化在线调查。
共有71个中心纳入分析。22个中心（31.0%）使用诊断性微生物组分析，但只有少数中心频繁（2个；2.8%）或定期（1个；1.4%）进行分析。11个中心（15.5%）已将FMT作为一种治疗方法。这些中心大多数采用个体化的内部供体筛查程序（61.5%）。三分之一（33.8%）的中心认为FMT的治疗效果高或中等。超过三分之二（69.0%）的参与者愿意参与评估FMT治疗效果的研究。
制定儿科患者微生物组分析和FMT的指南以及调查其益处的临床研究对于改善儿科胃肠病学以患者为中心的护理绝对必要。为获得安全的治疗方法，迫切需要长期成功建立具有标准化患者选择、供体筛查、应用途径、剂量和使用频率程序的儿科FMT中心。
