Medical Cyclotron Facility, Regional Centre, Board of Radiation and Isotope Technology, VECC, Kolkata, India.
Medical Cyclotron Facility, Regional Centre, Board of Radiation and Isotope Technology, VECC, Kolkata, India.
Appl Radiat Isot. 2023 May;195:110744. doi: 10.1016/j.apradiso.2023.110744. Epub 2023 Feb 26.
Ga is produced from enriched zinc-68 target electrodeposited on copper base material which was irradiated with 15 MeV proton energy in 30 MeV cyclotron. A modified semi-automated separation and purification module was used to obtain pharmaceutical grade [Ga]GaCl in 35 ± 5 min. The quality of [Ga]GaCl produced was in accordance with Pharmeuropa 30.4. The [Ga]GaCl was utilized for the formulation of multiple doses of [Ga]Ga-PSMA-11 and [Ga]Ga-DOTATATE. The quality of [Ga]Ga-PSMA-11 and [Ga]Ga-DOTATATE were also in accordance with Pharmacopeia.
镓是从铜基底材料上用电沉积方法富集锌-68 靶材得到的，该铜基底材料曾在 30MeV 回旋加速器中用 15MeV 质子能量辐照。采用改良的半自动分离纯化模块，可在 35±5 分钟内获得医药级[Ga]GaCl。所生产的[Ga]GaCl 的质量符合 Pharmeuropa 30.4。[Ga]GaCl 用于配制多剂量[Ga]Ga-PSMA-11 和[Ga]Ga-DOTATATE。[Ga]Ga-PSMA-11 和[Ga]Ga-DOTATATE 的质量也符合药典标准。
