Karolinska University Hospital, Department of Medical Radiation Physics and Nuclear Medicine, Eugeniavägen 3, SE- 171 76, Stockholm, Sweden; Karolinska Institutet, Department of Oncology and Pathology, Akademiska stråket 1, SE-171 64, Stockholm, Sweden.
Karolinska University Hospital, Department of Radiopharmacy, Stockholm, Sweden, Akademiska stråket 1, SE-171 64, Stockholm, Sweden; Karolinska Institutet, Department of Oncology and Pathology, Akademiska stråket 1, SE-171 64, Stockholm, Sweden.
Appl Radiat Isot. 2021 Oct;176:109825. doi: 10.1016/j.apradiso.2021.109825. Epub 2021 Jun 12.
The growing need and limited availability of generator produced Ga (T = 68 min) for PET has provided the impetus for alternative, high output, Ga production routes such as charge particle activation of enriched Zn using PET cyclotrons. The work presents a rapid production method for clinically useful Ga for radiolabeling. The focus is also to expand the production capacity of cyclotron solid target-produced Ga over generator produced and liquid solutions targets by using enriched Zn-foils that minimizes target preparation.
对于正电子发射断层扫描（PET）而言，由于对发电机生产的镓（T=68 分钟）的需求不断增长，而供应量有限，因此需要替代的、高产量的镓生产途径，例如使用 PET 回旋加速器对富集锌进行带电粒子激活。这项工作提出了一种用于放射性标记的临床有用镓的快速生产方法。重点还在于通过使用最小化目标制备的富集锌箔来扩大回旋加速器固体靶生产的镓相对于发电机生产和液体溶液靶的生产能力。
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