Department of Psychology, University of Houston, USA.
Department of Psychology, University of Houston, USA; Department of Behavioral Sciences, University of Texas MD Anderson Cancer Center, USA; Health Institute, University of Houston, USA.
Addict Behav. 2023 Jul;142:107668. doi: 10.1016/j.addbeh.2023.107668. Epub 2023 Feb 18.
Trauma-exposure and posttraumatic stress symptoms increase risk for opioid-related problems in the context of chronic pain. Yet, there has been little exploration of moderators of the posttraumatic stress-opioid misuse association. Pain-related anxiety, defined as worry about pain and the negative consequences of pain, has shown relations to both posttraumatic stress symptoms and opioid misuse, and it may moderate the association between posttraumatic stress symptoms and opioid misuse, as well as dependence. The current study examined the moderating role of pain-related anxiety on the relationship between posttraumatic stress symptoms and opioid misuse and dependence among 292 (71.6 % female, M = 38.03 years, SD = 10.93) trauma exposed adults with chronic pain. Results indicated that pain-related anxiety significantly moderated the observed relations, such that compared to those with low pain-related anxiety, the relationship between posttraumatic stress symptoms and opioid misuse and dependence was stronger for those with elevated pain-related anxiety. These results highlight the importance of assessing and targeting pain-related anxiety among this trauma-exposed segment of the chronic pain population with elevated posttraumatic stress symptoms.
创伤暴露和创伤后应激症状会增加慢性疼痛患者阿片类药物相关问题的风险。然而，对于创伤后应激与阿片类药物滥用之间的调节因素，研究还很少。疼痛相关焦虑是指对疼痛及其负面后果的担忧，它与创伤后应激症状和阿片类药物滥用都有关，并且可能调节创伤后应激症状与阿片类药物滥用和依赖之间的关系。本研究调查了疼痛相关焦虑在 292 名（71.6%为女性，平均年龄 38.03 岁，标准差 10.93）创伤后慢性疼痛成年人中，创伤后应激症状与阿片类药物滥用和依赖之间关系的调节作用。结果表明，疼痛相关焦虑显著调节了观察到的关系，即与疼痛相关焦虑较低的人相比，疼痛相关焦虑较高的人，创伤后应激症状与阿片类药物滥用和依赖之间的关系更强。这些结果强调了在创伤后应激症状较高的慢性疼痛人群中，评估和治疗疼痛相关焦虑的重要性。
