Department of Psychology, University of Houston, Houston, TX, USA.
Department of Psychology, Ohio University, USA.
Psychiatry Res. 2020 Dec;294:113523. doi: 10.1016/j.psychres.2020.113523. Epub 2020 Oct 22.
The United States (US) population consumes an estimated 68% of the world's prescribed opioids each year, and over 2 million adults in the US suffer from an opioid use disorder. Although chronic pain populations are among the highest risk segments of the general population for opioid misuse and dependence, there is little understanding of individual risk characteristics that may contribute to greater risk for these outcomes among this group. The present investigation explored the concurrent role of anxiety sensitivity and pain intensity and their interaction in relation to opioid misuse and dependence among 429 adults with chronic pain (73.9% female, M = 38.32 years, SD = 11.07). Results revealed that both anxiety sensitivity and pain intensity were associated with opioid misuse and dependence. There was no evidence of an interaction for either outcome. Post-hoc analyses indicated that of the lower-order anxiety sensitivity facets, physical and mental incapacitation concerns contributed to variance in opioid misuse and only mental incapacitation concerns contributed to variance in opioid dependence. Overall, the current findings suggest the importance of assessing anxiety sensitivity in screening for opioid-related problems among persons with chronic pain, as it may represent a distinct pathway to poorer opioid-related outcomes among this group.
美国（US）人口每年消耗的处方类阿片约占全球的 68%，美国有超过 200 万成年人患有阿片类药物使用障碍。尽管慢性疼痛人群是普通人群中阿片类药物滥用和依赖风险最高的群体之一，但对于可能导致这一群体出现更高风险的个体风险特征知之甚少。本研究探讨了焦虑敏感性和疼痛强度及其相互作用在 429 名慢性疼痛成年人（73.9%为女性，M=38.32 岁，SD=11.07）中与阿片类药物滥用和依赖的关系。结果表明，焦虑敏感性和疼痛强度都与阿片类药物滥用和依赖有关。两种结果都没有证据表明存在相互作用。事后分析表明，在较低阶的焦虑敏感性特征中，身体和心理失能的担忧与阿片类药物滥用的差异有关，而只有心理失能的担忧与阿片类药物依赖的差异有关。总体而言，目前的研究结果表明，在对慢性疼痛患者进行阿片类药物相关问题筛查时，评估焦虑敏感性的重要性，因为它可能代表了这一群体中更差的阿片类药物相关结果的一个独特途径。
