Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA; Research Service, VA San Diego Healthcare System, San Diego, CA, USA.
Neurobiol Aging. 2023 May;125:83-89. doi: 10.1016/j.neurobiolaging.2023.01.012. Epub 2023 Feb 2.
Higher cognitive reserve (CR) may offer protection from cognitive changes associated with reduced cerebral blood flow (CBF). We investigated CR as a moderator of the effect of CBF on cognition in older adults with mild cognitive impairment (MCI; N = 46) and those who are cognitively unimpaired (CU; N = 101). Participants underwent arterial spin labeling MRI, which was used to quantify CBF in 4 a priori regions. Estimated verbal intelligence quotient (VIQ) served as a proxy for CR. Multiple linear regressions examined whether VIQ moderated associations between CBF and cognition and whether this differed by cognitive status. Outcomes included memory and language performance. There were 3-way interactions (CBFVIQcognitive status) on category fluency when examining hippocampal, superior frontal, and inferior frontal CBF. Follow-up analyses revealed that, within the MCI but not CU group, there were CBF*VIQ interactions on fluency in all a priori regions examined, where there were stronger, positive associations between CBF and fluency at higher VIQ. Conclusion: In MCI, higher CR plays a role in strengthening CBF-fluency associations.
更高的认知储备（CR）可能提供对与脑血流（CBF）减少相关的认知变化的保护。我们研究了 CR 作为认知储备的调节剂，以探讨其对轻度认知障碍（MCI；N=46）和认知未受损（CU；N=101）的老年人的 CBF 对认知的影响。参与者接受动脉自旋标记 MRI 检查，用于量化 4 个先验区域的 CBF。估计的言语智商（VIQ）作为 CR 的替代指标。多元线性回归检验了 VIQ 是否调节了 CBF 和认知之间的关联，以及这是否因认知状态而异。结果包括记忆力和语言表现。当检查海马、额上回和额下回的 CBF 时，存在 CBFVIQ认知状态的三向交互作用。后续分析表明，在 MCI 组而不是 CU 组中，在所有先验区域中，均存在 CBF*VIQ 交互作用，在更高的 VIQ 水平上，CBF 与流畅性之间存在更强的正相关。结论：在 MCI 中，更高的 CR 起到了增强 CBF-流畅性关联的作用。
