Ji Daolin, Feng Haonan, Hou Li, Xu Yi, Wang Xiuhong, Zhao Weili, Pei Hongyu, Zhao Qi, Chen Qian, Tan Gang
Department of Hepatopancreatobiliary Surgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China; The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, China.
Department of Hepatopancreatobiliary Surgery, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, China.
Pathol Res Pract. 2023 Apr;244:154382. doi: 10.1016/j.prp.2023.154382. Epub 2023 Feb 20.
The digestive system malignant tumors (DSMTs), mainly consist of digestive tract and digestive gland tumors, become an inescapable culprit to hazard human health worldwide. Due to the huge hysteresis in the cognitive theories of DSMTs occurrence and progression, advances in medical technology have not improved the prognosis. Therefore, more studies on a variety of tumor-associated molecular biomarkers and more detailed disclosure on potential regulatory networks are urgently needed to facilitate the diagnostic and therapeutic strategies of DSMTs. With the development of cancer bioinformatics, a special type of endogenous RNA involved in multi-level cellular function regulation rather than encoding protein, is categorized as non-coding RNAs (ncRNAs) and becomes a hotspot issue in oncology. Among them, long non-coding RNAs (lncRNAs), transcription length > 200 nt, show obvious superiority in both research quantity and dimension compared to microRNAs (miRNAs) and circular RNAs (circRNAs). As a recently discovered lncRNA, LINC00511 has been confirmed to be closely associated with DSMTs and might be exploited as a novel biomarker. In the present review, the comprehensive studies of LINC00511 in DSMTs are summarized, as well as the underlying molecular regulatory networks. In addition, deficiencies in researches are point out and discussed. The Cumulative oncology studies provide a fully credible theoretical basis for identifying the regulatory role of LINC00511 in human DSMTs. LINC00511, proved to be an oncogene in DSMTs, might be defined as a potential biomarker for diagnosis and prognosis evaluation, as well as a rare therapeutic target.
消化系统恶性肿瘤（DSMTs）主要由消化道和消化腺肿瘤组成，已成为全球危害人类健康的一大“元凶”。由于DSMTs发生和发展的认知理论存在巨大滞后性，医学技术的进步并未改善其预后。因此，迫切需要开展更多关于各种肿瘤相关分子生物标志物的研究，并更详细地揭示潜在的调控网络，以推动DSMTs的诊断和治疗策略。随着癌症生物信息学的发展，一类特殊的内源性RNA，其参与多层次细胞功能调控而非编码蛋白质，被归类为非编码RNA（ncRNAs），并成为肿瘤学中的热点问题。其中，转录长度>200 nt的长链非编码RNA（lncRNAs）在研究数量和维度上相较于微小RNA（miRNAs）和环状RNA（circRNAs）均显示出明显优势。作为最近发现的lncRNA，LINC00511已被证实与DSMTs密切相关，可能被开发为一种新型生物标志物。在本综述中，总结了LINC00511在DSMTs中的综合研究以及潜在的分子调控网络。此外，还指出并讨论了研究中的不足之处。累积的肿瘤学研究为确定LINC00511在人类DSMTs中的调控作用提供了充分可靠的理论依据。LINC00511在DSMTs中被证明是一种癌基因，可能被定义为诊断和预后评估的潜在生物标志物，以及一种罕见的治疗靶点。
