Department of Gynaecology, Daqing Oilfield General Hospital, Daqing, Heilongjiang 163000, China.
Department of Gynaecology, Rizhao Central Hospital, Rizhao, Shandong 7963622, China.
Biosci Rep. 2019 Sep 13;39(9). doi: 10.1042/BSR20190903. Print 2019 Sep 30.
LINC00511 is a newly identified lncRNA that is up-regulated in many types of human cancers and may serve as an oncogenic lncRNA. However, there was no report about the role of LINC00511 in cervical cancer. Therefore, we investigated the clinical value of LINC00511 in cervical cancer patients via analyzing the correlation between LINC00511 expression and clinicopathological features. Moreover, we performed loss-of-function study to estimate the effect of LINC00511 on cervical cancer cell proliferation, migration, and invasion. In our study, we found LINC00511 expression levels were increased in cervical cancer tissues and cell lines compared with adjacent normal tissues and normal cervical epithelial cell line, respectively. High LINC00511 expression was correlated with advanced clinical stage, large tumor size, histological type of adenocarcinoma, and present lymph node metastasis, distant metastasis, and poor overall survival in cervical cancer patients. The studies indicated that knockdown of LINC00511 inhibited cervical cancer cell proliferation, migration, and invasion. In conclusion, LINC00511 acts as oncogenic lncRNA in cervical cancer, and may be a novel biomarker and potential therapeutic target for cervical cancer patients.
LINC00511 是一种新鉴定的长链非编码 RNA，在许多人类癌症中上调，可能作为致癌性长链非编码 RNA。然而，目前尚无关于 LINC00511 在宫颈癌中的作用的报道。因此，我们通过分析 LINC00511 表达与临床病理特征之间的相关性，研究了 LINC00511 在宫颈癌患者中的临床价值。此外，我们进行了功能丧失研究，以评估 LINC00511 对宫颈癌细胞增殖、迁移和侵袭的影响。在我们的研究中，我们发现与相邻正常组织和正常宫颈上皮细胞系相比，LINC00511 在宫颈癌组织和细胞系中的表达水平升高。LINC00511 高表达与宫颈癌患者的晚期临床分期、大肿瘤大小、腺癌组织学类型、淋巴结转移、远处转移和总体生存不良相关。这些研究表明，敲低 LINC00511 抑制了宫颈癌细胞的增殖、迁移和侵袭。总之，LINC00511 在宫颈癌中作为致癌性长链非编码 RNA 发挥作用，可能成为宫颈癌患者的新型生物标志物和潜在治疗靶点。
