在3D仿生模型中重现的年龄相关性黄斑变性：视网膜组织工程的一项突破。
AMD recapitulated in a 3D biomimetic: A breakthrough in retina tissue engineering.
作者信息
Dalvi Sonal, Chatterjee Amit, Singh Ruchira
机构信息
Department of Ophthalmology, University of Rochester, Rochester, NY 14620, USA; Center for Visual Science, University of Rochester, Rochester, NY 14620, USA.
Department of Ophthalmology, University of Rochester, Rochester, NY 14620, USA; Department of Biomedical Genetics, University of Rochester, Rochester, NY 14620, USA; Center for Visual Science, University of Rochester, Rochester, NY 14620, USA; UR Stem Cell and Regenerative Medicine Center, Rochester, NY 14620, USA.
出版信息
Cell Stem Cell. 2023 Mar 2;30(3):243-245. doi: 10.1016/j.stem.2023.02.001.
Song et al. (Nature Methods, 2022) engineered a 3D model of the human outer blood-retina barrier (oBRB) that recapitulates key features of healthy and age-related macular degeneration (AMD)-affected eyes. We shine a spotlight on this tissue-engineering triumph that has the potential to transform preclinical studies of AMD and other eye diseases.
宋等人（《自然方法》，2022年）构建了一种人类视网膜外血视网膜屏障（oBRB）的三维模型，该模型概括了健康眼睛和与年龄相关的黄斑变性（AMD）受累眼睛的关键特征。我们聚焦于这一组织工程学上的重大成就，它有可能改变AMD及其他眼部疾病的临床前研究。
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