Department of Aquatic Life Medicine, Pukyong National University, Busan, 608-737, Republic of Korea.
Department of Aquatic Life and Medical Science, Sun Moon University, Asan-si, Republic of Korea.
Fish Shellfish Immunol. 2023 Apr;135:108658. doi: 10.1016/j.fsi.2023.108658. Epub 2023 Mar 1.
The purpose of this study is to investigate the effect of inorganic mercury (Hg) on fish. Inorganic Hg is less toxic than organic Hg, but it is used more in human daily life, such as manufacturing Hg batteries and fluorescent lamps. For this reason, inorganic Hg was used in this study. Starry flounder, Platichthys stellatus (mean weight 43.9 ± 4.4 g; mean length 14.2 ± 0.4 cm) were exposed for 4 weeks to the different levels of dietary inorganic Hg at concentrations of 0, 4, 8, 12 and 16 mg Hg/kg, and depuration was performed for 2 weeks after exposure. Bioaccumulation of Hg in the tissues was observed to increase significantly, in following order: intestine > head kidney > liver > gills > muscle. Antioxidant responses (superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST) and glutathione (GSH)) were significantly increased. Immune responses (lysozyme and phagocytosis activity) were substantially decreased. The results of this study suggest that dietary inorganic Hg induces bioaccumulation in specific tissues, increases antioxidant responses and decreases immune responses. After the depuration period for 2 weeks, it was effective to alleviate bioaccumulation in tissues. However, antioxidant and immune responses were limited to be attenuated for recovery.
本研究旨在探讨无机汞（Hg）对鱼类的影响。无机汞的毒性比有机汞低，但在人类日常生活中使用得更广泛，例如制造汞电池和荧光灯。出于这个原因，本研究中使用了无机汞。星鲽（Platichthys stellatus）（平均体重 43.9±4.4g；平均长度 14.2±0.4cm）在 4 周内暴露于不同水平的膳食无机汞中，浓度分别为 0、4、8、12 和 16mg Hg/kg，暴露后进行 2 周的净化。观察到 Hg 在组织中的生物累积显著增加，以下列顺序为：肠道>头肾>肝脏>鳃>肌肉。抗氧化反应（超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽-S-转移酶（GST）和谷胱甘肽（GSH））显著增加。免疫反应（溶菌酶和吞噬活性）显著降低。本研究结果表明，膳食无机汞会导致特定组织中的生物累积，增加抗氧化反应，降低免疫反应。经过 2 周的净化期后，有效缓解了组织中的生物累积。然而，抗氧化和免疫反应的恢复受到限制。
