Dionysakopoulou Christina, Lianou Loukia, Boutopoulou Barbara, Giannakopoulou Margarita, Vlachioti Efrosini, Koumpagioti Despoina, Bozas Evangelos, Matziou Vasiliki
Neonatal Netw. 2023 Mar 1;42(2):65-71. doi: 10.1891/NN.2022-0006.
Our aim was to investigate biomarkers of neonatal pain and their association with two pain scales. This prospective study included 54 full-term neonates. Levels of substance P (SubP), neurokinin A (NKA), neuropeptide Y (NPY), and cortisol were recorded and two pain scales (Premature Infant Pain Profile [PIPP] and Neonatal Infant Pain Scale [NIPS]) were used. A statistically significant decrease in the levels of NPY ( = 0.02) and NKA ( = 0.03) was detected. A significant increase in NIPS scale ( < 0.001) and PIPP scale ( < 0.001) postpainful intervention was also detected. There was a positive correlation between cortisol and SubP ( = 0.01), NKA and NPY ( < 0.001) and between NIPS and PIPP ( < 0.001). A negative correlation was found for NPY with SubP ( = 0.004), cortisol ( = 0.02), NIPS ( = 0.001) and PIPP ( = 0.002). Novel biomarkers and pain scales may help in designing an objective tool for the quantification of neonatal pain in the everyday practice.
我们的目的是研究新生儿疼痛的生物标志物及其与两种疼痛量表的关联。这项前瞻性研究纳入了54名足月儿。记录了P物质（SubP）、神经激肽A（NKA）、神经肽Y（NPY）和皮质醇的水平，并使用了两种疼痛量表（早产儿疼痛量表[PIPP]和新生儿疼痛量表[NIPS]）。检测到NPY（P = 0.02）和NKA（P = 0.03）水平有统计学意义的下降。疼痛干预后，NIPS量表（P < 0.001）和PIPP量表（P < 0.001）也有显著升高。皮质醇与SubP（P = 0.01）、NKA与NPY（P < 0.001）以及NIPS与PIPP（P < 0.001）之间存在正相关。发现NPY与SubP（P = 0.004）、皮质醇（P = 0.02）、NIPS（P = 0.001）和PIPP（P = 0.002）之间存在负相关。新的生物标志物和疼痛量表可能有助于在日常实践中设计一种客观的工具来量化新生儿疼痛。
